1887

Abstract

We describe the case of a 16-year-old German male expatriate from Ghana who presented with obstipation, dysuria, dysaesthesia of the gluteal region and the lower limbs, bilateral plantar hypaesthesia and paraesthesia without pareses. A serum–cerebrospinal fluid (CSF) spp. specific antibody specificity index of 3.1 was considered highly suggestive of intrathecal synthesis of anti- spp. specific antibodies, although standardization of this procedure has not previously been described. Diagnosis was confirmed by detection of DNA in CSF by semi-quantitative real-time PCR at 100-fold concentration compared with serum. Accordingly the two diagnostic procedures, which have not previously been applied for routine diagnosis, appear to be useful for the diagnosis of neuroschistosomiasis. Clinical symptoms resolved following anthelmintic and anti-inflammatory therapy.

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2014-02-01
2019-12-14
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References

  1. Alves W. . ( 1958; ). The distribution of Schistosoma eggs in human tissues. . Bull World Health Organ 18:, 1092–1097.[PubMed]
    [Google Scholar]
  2. Andiman W. A. . ( 1991; ). Organism-specific antibody indices, the cerebrospinal fluid-immunoglobulin index and other tools: a clinician’s guide to the etiologic diagnosis of central nervous system infection. . Pediatr Infect Dis J 10:, 490–495. [CrossRef] [PubMed]
    [Google Scholar]
  3. Carod-Artal F. J. . ( 2008; ). Neurological complications of Schistosoma infection. . Trans R Soc Trop Med Hyg 102:, 107–116. [CrossRef] [PubMed]
    [Google Scholar]
  4. Ferrari T. C. . ( 2010; ). A laboratory test for the diagnosis of neuroschistosomiasis. . Neurol Res 32:, 252–262. [CrossRef] [PubMed]
    [Google Scholar]
  5. Ferrari T. C. , Moreira P. R. , Oliveira R. C. , Ferrari M. L. , Gazzinelli G. , Cunha A. S. . ( 1995; ). The value of an enzyme-linked immunosorbent assay for the diagnosis of schistosomiasis mansoni myeloradiculopathy. . Trans R Soc Trop Med Hyg 89:, 496–500. [CrossRef] [PubMed]
    [Google Scholar]
  6. Ferrari T. C. , Moreira P. R. , Cunha A. S. . ( 2004; ). Spinal cord schistosomiasis: a prospective study of 63 cases emphasizing clinical and therapeutic aspects. . J Clin Neurosci 11:, 246–253. [CrossRef] [PubMed]
    [Google Scholar]
  7. Ferrari T. C. , Gazzinelli G. , Corrêa-Oliveira R. . ( 2008; ). Immune response and pathogenesis of neuroschistosomiasis mansoni. . Acta Trop 108:, 83–88. [CrossRef] [PubMed]
    [Google Scholar]
  8. Ferrari T. C. , Faria L. C. , Vilaca T. S. , Correa C. R. , Goes A. M. . ( 2011; ). Identification and characterization of immune complexes in the cerebrospinal fluid of patients with spinal cord schistosomiasis. . J Neuroimmunol 230:, 188–190.[CrossRef]
    [Google Scholar]
  9. Gelfand M. . ( 1950; ). Schistosomiasis in South Central Africa, pp. 194–202. Capetown, South Africa:: Post Graduate Press;.
    [Google Scholar]
  10. Gryseels B. , Polman K. , Clerinx J. , Kestens L. . ( 2006; ). Human schistosomiasis. . Lancet 368:, 1106–1118. [CrossRef] [PubMed]
    [Google Scholar]
  11. Imai K. , Koibuchi T. , Kumagai T. , Maeda T. , Osada Y. , Ohta N. , Koga M. , Nakamura H. , Miura T. . & other authors ( 2011; ). Cerebral schistosomiasis due to Schistosoma haematobium confirmedby PCR analysis of brain specimen. . J Clin Microbiol 49:, 3703–3706. [CrossRef] [PubMed]
    [Google Scholar]
  12. Jauréguiberry S. , Ansart S. , Perez L. , Danis M. , Bricaire F. , Caumes E. . ( 2007; ). Acute neuroschistosomiasis: two cases associated with cerebral vasculitis. . Am J Trop Med Hyg 76:, 964–966.[PubMed]
    [Google Scholar]
  13. Koul R. , Alexander P. , Scrimgeour E. , Idris M. , Joseph K. . ( 2002; ). Schistosoma mansoni myeloradiculopathy in an 8-year-old Omani boy. . J Trop Pediatr 48:, 183–186. [CrossRef] [PubMed]
    [Google Scholar]
  14. Li Y. , Ross A. G. , Hou X. , Lou Z. , McManus D. P. . ( 2011; ). Oriental schistosomiasis with neurological complications: case report. . Ann Clin Microbiol Antimicrob 10:, 5–10. [CrossRef] [PubMed]
    [Google Scholar]
  15. Liu L. X. . ( 1993; ). Spinal and cerebral schistosomiasis. . Semin Neurol 13:, 189–200. [CrossRef] [PubMed]
    [Google Scholar]
  16. Liu H. Q. , Feng X. Y. , Yao Z. W. , Sun H. P. . ( 2006; ). Characteristic magnetic resonance enhancement pattern in cerebral schistosomiasis. . Chin Med Sci J 21:, 223–227.[PubMed]
    [Google Scholar]
  17. Magalhães-Santos I. F. , Lemaire D. C. , Andrade-Filho A. S. , Queiroz A. C. , Carvalho O. M. , Carmo T. M. , Siqueira I. C. , Andrade D. M. , Rego M. F. . & other authors ( 2003; ). Antibodies to Schistosoma mansoni in human cerebrospinal fluid. . Am J Trop Med Hyg 68:, 294–298.[PubMed]
    [Google Scholar]
  18. Moreno-Carvalho O. A. , Nascimento-Carvalho C. M. , Bacelar A. L. , Andrade-Filho A. S. , Costa G. , Fontes J. B. , Assis T. . ( 2003; ). Clinical and cerebrospinal fluid (CSF) profile and CSF criteria for the diagnosis of spinal cord schistosomiasis. . Arq Neuropsiquiatr 61:(2B), 353–358. [CrossRef] [PubMed]
    [Google Scholar]
  19. Pammenter M. D. , Epstein S. R. , Rees R. T. . ( 1992; ). Cross reactions in the immunodiagnosis of schistosomiasis and cysticercosis by a cerebrospinal fluid enzyme-linked immunosorbent assay. . Trans R Soc Trop Med Hyg 86:, 51–52. [CrossRef] [PubMed]
    [Google Scholar]
  20. Pollner J. H. , Schwartz A. , Kobrine A. , Parenti D. M. . ( 1994; ). Cerebral schistosomiasis caused by Schistosoma haematobium: case report. . Clin Infect Dis 18:, 354–357. [CrossRef] [PubMed]
    [Google Scholar]
  21. Tesser E. , Reis Mde L. , Borelli P. , Matas S. L. , Reis Filho J. B. . ( 2005; ). [Cerebrospinal fluid in the diagnosis of spinal schistosomiasis]. . Arq Neuropsiquiatr 63:(3A), 661–665 (in Portuguese).[PubMed] [CrossRef]
    [Google Scholar]
  22. Wang P. , Wu M. C. , Chen S. J. , Luo G. C. , Cheng X. L. , Zhu Z. S. , Zhao G. R. . ( 2010; ). Research development of the pathogenesis pathways for neuroschistosomiasis. . Neurosci Bull 26:, 168–174. [CrossRef] [PubMed]
    [Google Scholar]
  23. Wichmann D. , Hofmann C. , Sudeck H. , Burchard G. D. , Moser A. . ( 2006; ). Myeloradiculitis: a rare event in schistosoma infection. . Infection 34:, 349–351. [CrossRef] [PubMed]
    [Google Scholar]
  24. Wichmann D. , Panning M. , Quack T. , Kramme S. , Burchard G. D. , Grevelding C. , Drosten C. . ( 2009; ). Diagnosing schistosomiasis by detection of cell-free parasite DNA in human plasma. . PLoS Negl Trop Dis 3:, e422. [CrossRef] [PubMed]
    [Google Scholar]
  25. Wichmann D. , Poppert S. , Von Thien H. , Clerinx J. , Dieckmann S. , Jensenius M. , Parola P. , Richter J. , Schunk M. . & other authors ( 2013; ). Prospective European-wide multicentre study on a blood based real-time PCR for the diagnosis of acute schistosomiasis. . BMC Infect Dis 13:, 55. [CrossRef] [PubMed]
    [Google Scholar]
  26. Zhou J. , Li G. , Xia J. , Xiao B. , Bi F. , Liu D. , Chen C. . ( 2009; ). Cerebral schistosomiasis japonica without gastrointestinal system involvement. . Surg Neurol 71:, 481–486. [CrossRef] [PubMed]
    [Google Scholar]
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