1887

Abstract

Carbapenem-resistant have been frequently reported worldwide. They represent a serious concern because of the limited therapeutic options. The aim of this study was to investigate the molecular epidemiology of 14 carbapenemase (KPC) producers among 345 clinical isolates of with reduced susceptibility to carbapenems recovered from 11 separate hospitals in southern Brazil. The gene was detected in 14 isolates (4 %): six , five and three . Most of these isolates exhibited high-level resistance against β-lactams and ciprofloxacin, while the most active drugs were polymyxin B and amikacin. Genetic environment analysis, based on the classical Tn structure, revealed six distinct platforms. Plasmids carrying were not typable and most were approximately 20 kb. Only KPC carbapenemases were found among the isolates studied, highlighting the local relevance of these enzymes in acquired resistance to carbapenems in . Our results contribute to the understanding of carbapenem resistance in and to the molecular characterization of KPC-2-producing isolates in Brazil.

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2013-11-01
2019-12-13
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