1887

Abstract

In recent decades the incidence of endocarditis has increased dramatically. Despite the application of surgery and antifungal therapy, endocarditis remains a life-threatening infection with significant morbidity and mortality. We report a 37-year-old male drug abuser presenting with high fever, chest pain, loss of appetite and cardiac failure. His echocardiography revealed mobile large tricuspid valve vegetations. Fungal endocarditis was confirmed by culturing of the resected vegetation showing mixed growth of and , although three consecutive blood cultures were negative for species. Phenotypic identification was reconfirmed by sequencing of the internal transcribed spacer (ITS rDNA) region. The patient was initially treated with intravenous fluconazole (6 mg kg per day), followed by 2 weeks of intravenous amphotericin B deoxycholate (1 mg kg per day). Although MICs were low for both drugs, the patient’s antifungal therapy combined with valve replacement failed, and he died due to respiratory failure.

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2013-11-01
2022-05-29
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