1887

Abstract

Among 28 clinically relevant, carbapenem non-susceptible isolates collected in 2009–2011 in the United Arab Emirates three , two , one and one were identified to produce NDM-1 carbapenemase. Unexpectedly, with the exception of a strain, sequence type ST11, originally acquired in India and subsequently spread nosocomially in the UAE, the majority of the strains could not be directly linked to foreign travel. All isolates harboured the gene on plasmids of IncA/C, IncHI1b and IncX3 types, or were untypable. IncX3 type plasmids with a mass of 50 kb and with the same or highly similar restriction patterns, with regions flanking the gene identical to the IncX3 NDM plasmids described from China were present in three different species, , and . Our findings strongly support the assumptions that, beyond the Indian subcontinent, the Middle East is an important reservoir of NDM-producing organisms. Furthermore, we also provide evidence that IncX3 plasmids, recently implicated in the spread of in China, have been widely distributed and are important vehicles of the inter-species spread of the NDM-1 gene.

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2013-07-01
2024-03-29
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