1887

Abstract

Specimens from men with acute non-gonococcal urethritis were tested to determine their microbial content and then given intra-urethrally to male chimpanzees. Two animals received ureaplasmas only and one became infected. The second did so when given a different strain. Both developed a polymorphonuclear leukocyte (PMNL) response. Two chimpanzees received a mixture of ureaplasmas and and there was a suggestion that the ureaplasmas delayed or suppressed the chlamydial response. The latter, that is urethral infection with a pronounced PMNL response, was most clearly seen in a chimpanzee given only. No inflammation was detected in two chimpanzees acting as controls. Three of five chimpanzees given ureaplasmas genitally, and one that had them endogenously, had them transiently in the oropharynx about 2 weeks later. The occurrence of ureaplasmas in the conjunctiva of three chimpanzees inoculated at this site was also transient and without inflammation. The possibility that might have been in the inocula and caused urethral inflammation was discounted largely because no animal had antibody to this mycoplasma.

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2013-10-01
2024-04-18
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References

  1. Furr P. M., Taylor-Robinson D. 1984; Microimmunofluorescence technique for detection of antibody to Mycoplasma genitalium . J Clin Pathol 37:1072–1074 [View Article][PubMed]
    [Google Scholar]
  2. Jacobs N. F. Jr, Arum E. S., Kraus S. J. 1978; Experimental infection of the chimpanzee urethra and pharynx with Chlamydia trachomatis . Sex Transm Dis 5:132–136 [View Article][PubMed]
    [Google Scholar]
  3. Mouches C., Taylor-Robinson D., Stipkovits L., Bove J. M. 1981; Comparison of human and animal ureaplasmas by one- and two-dimensional protein analysis on polyacrylamide slab gel. Ann Microbiol (Paris) 132B:171–196[PubMed]
    [Google Scholar]
  4. Ondondo R. O., Whittington W. L., Astete S. G., Totten P. A. 2010; Differential association of ureaplasma species with non-gonococcal urethritis in heterosexual men. Sex Transm Infect 86:271–275 [View Article][PubMed]
    [Google Scholar]
  5. Purcell R. H., Taylor-Robinson D., Wong D., Chanock R. M. 1966; Color test for the measurement of antibody to T-strain mycoplasmas. J Bacteriol 92:6–12[PubMed]
    [Google Scholar]
  6. Taylor-Robinson D. 1984a; Mycoplasma infections of the human urogenital tract with particular reference to non-gonococcal urethritis. Ann Microbiol (Paris) 135A:129–134[PubMed]
    [Google Scholar]
  7. Taylor-Robinson D. 1984b; Ureaplasmas as a cause of disease in man and animals: fact or fancy?. Isr J Med Sci 20:843–847[PubMed]
    [Google Scholar]
  8. Taylor-Robinson D. 1985; Mycoplasmal and mixed infections of the human male urogenital tract and their possible complications. In The Mycoplasmas, vol. 4 Mycoplasma Pathogenicity pp. 27–63 Edited by Razin S., Barile M. F. New York, NY: Academic Press; [CrossRef]
    [Google Scholar]
  9. Taylor-Robinson D., Furr P. M. 1981; Recovery and identification of human genital tract mycoplasmas. Isr J Med Sci 17:648–653[PubMed]
    [Google Scholar]
  10. Taylor-Robinson D., Purcell R. H., London W. T., Sly D. L. 1978; Urethral infection of chimpanzees by Ureaplasma urealyticum . J Med Microbiol 11:197–201 [View Article][PubMed]
    [Google Scholar]
  11. Taylor-Robinson D., Purcell R. H., London W. T., Sly D. L., Thomas B. J., Evans R. T. 1981a; Microbiological, serological, and histopathological features of experimental Chlamydia trachomatis urethritis in chimpanzees. Br J Vener Dis 57:36–40[PubMed]
    [Google Scholar]
  12. Taylor-Robinson D., Furr P. M., Davies H. A., Manchee R. J., Mouches C., Bove J. M. 1981b; Mycoplasmal adherence with particular reference to the pathogenicity of Mycoplasma pulmonis . Isr J Med Sci 17:599–603[PubMed]
    [Google Scholar]
  13. Taylor-Robinson D., Johnson A. P., Tuffrey M. 1983; Animal models of ureaplasmal and chlamydial genital tract infection. In Experimental Bacterial and Parasitic Infections pp. 161–166 Edited by Keusch G., Wadstrom T. Oxford: Elsevier Biomedical;
    [Google Scholar]
  14. Taylor-Robinson D., Tully J. G., Barile M. F. 1985; Urethral infection in male chimpanzees produced experimentally by Mycoplasma genitalium. . Br J Exp Pathol 66:95–101[PubMed]
    [Google Scholar]
  15. Taylor-Robinson D., Barile M. F., Furr P. M., Graham C. E. 1987; Ureaplasmas and mycoplasmas in chimpanzees of various breeding capacities. J Reprod Fertil 81:169–173 [View Article][PubMed]
    [Google Scholar]
  16. Thomas B. J., Reeve P., Oriel J. D. 1976; Simplified serological test for antibodies to Chlamydia trachomatis . J Clin Microbiol 4:6–10[PubMed]
    [Google Scholar]
  17. Thomas B. J., Evans R. T., Hutchinson G. R., Taylor-Robinson D. 1977; Early detection of chlamydial inclusions combining the use of cycloheximide-treated McCoy cells and immunofluorescence staining. J Clin Microbiol 6:285–292[PubMed]
    [Google Scholar]
  18. Tuffrey M. A., Furr P. M., Falder P., Taylor-Robinson D. 1984; The anti-chlamydial effect of experimental Mycoplasma pulmonis infection in the murine genital tract. J Med Microbiol 17:357–362 [View Article][PubMed]
    [Google Scholar]
  19. Tully J. G., Taylor-Robinson D., Rose D. L., Furr P. M., Graham C. E., Barile M. F. 1986; Urogenital challenge of primate species with Mycoplasma genitalium and characteristics of infection induced in chimpanzees. J Infect Dis 153:1046–1054 [View Article][PubMed]
    [Google Scholar]
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