1887

Abstract

A case of subcutaneous phaeohyphomycosis caused by is reported in a 75-year-old female, who showed subcutaneous abscesses on both forearms for 8 months. A lesion was initiated by inoculation with a spine from a tree. Histopathologically, suppurative granulomatous inflammation was present and short hyphal elements were observed. Upon culture greyish–black, velvety colonies of a black yeast were obtained after 3 weeks. The strain grew well at 25 °C, but poorly at 37 °C. After sequencing the internal transcribed spacer domain and the partial β-tubulin gene, the fungus was identified as . The patient was successfully treated with fluconazole for 3 months.

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2013-05-01
2024-04-25
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References

  1. Badali H., Najafzadeh M. J., van Esbroeck M., van den Enden E., Tarazooie B., Meis J. F., de Hoog G. S. 2010; The clinical spectrum of Exophiala jeanselmei, with a case report and in vitro antifungal susceptibility of the species. Med Mycol 48:318–327 [View Article][PubMed]
    [Google Scholar]
  2. CLSI (2008). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard M38-A2 C. Wayne, PA: Clinical and Laboratory Standards Institute
  3. De Hoog G. S., Guarro J., Gene J., Figueras M. J. 2000 Atlas of Clinical Fungi,, 2nd ed. Utrecht/Reus: Centraalbureau voor Schimmelcultures/Universitat Rovira i Virgili;
    [Google Scholar]
  4. De Hoog G. S., Vicente V., Caligiorne R. B., Kantarcioglu S., Tintelnot K., Gerrits van den Ende A. H., Haase G. 2003; Species diversity and polymorphism in the Exophiala spinifera clade containing opportunistic black yeast-like fungi. J Clin Microbiol 41:4767–4778 [View Article][PubMed]
    [Google Scholar]
  5. De Hoog G. S., Vicente V. A., Najafzadeh M. J., Harrak M. J., Badali H., Seyedmousavi S. 2011; Waterborne Exophiala species causing disease in cold-blooded animals. Persoonia 27:46–72 [View Article][PubMed]
    [Google Scholar]
  6. Li D. M., de Hoog G. S., Saunte D. M., van den Ende A. H., Chen X. R. 2008; Coniosporium epidermidis sp. nov., a new species from human skin. Stud Mycol 61:131–136 [View Article][PubMed]
    [Google Scholar]
  7. Li D. M., Li R. Y., De Hoog G. S., Wang Y. X., Wang D. L. 2009; Exophiala asiatica, a new species from a fatal case in China. Med Mycol 47:101–109 [View Article][PubMed]
    [Google Scholar]
  8. Lian X., de Hoog G. S. 2010; Indoor wet cells harbour melanized agents of cutaneous infection. Med Mycol 48:622–628 [View Article][PubMed]
    [Google Scholar]
  9. Matsumoto T., Ajello L., Matsuda T., Szaniszlo P. J., Walsh T. J. 1994; Developments in hyalohyphomycosis and phaeohyphomycosis. J Med Vet Mycol 32:Suppl. 1329–349 [View Article][PubMed]
    [Google Scholar]
  10. Najafzadeh M. J., Badali H., Illnait-Zaragozi M. T., De Hoog G. S., Meis J. F. 2010; In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. Antimicrob Agents Chemother 54:1636–1638 [View Article][PubMed]
    [Google Scholar]
  11. Najafzadeh M. J., Vicente V. A., Sun J., Meis J. F., de Hoog G. S. 2011a; Fonsecaea multimorphosa sp. nov, a new species of Chaetothyriales isolated from a feline cerebral abscess. Fungal Biol 115:1066–1076 [View Article][PubMed]
    [Google Scholar]
  12. Najafzadeh M. J., Sun J., Vicente V. A., Klaassen C. H., Bonifaz A., Gerrits van den Ende A. H., Menken S. B., de Hoog G. S. 2011b; Molecular epidemiology of Fonsecaea species. Emerg Infect Dis 17:464–469 [View Article][PubMed]
    [Google Scholar]
  13. Pollacci G. 1923; Miceti del corpo umano e degli animali. Atti dell’Istituto Botanico Università di Pavia 18:1–9 (in Italian)
    [Google Scholar]
  14. Revankar S. G. 2007; Dematiaceous fungi. Mycoses 50:91–101 [View Article][PubMed]
    [Google Scholar]
  15. Revankar S. G., Sutton D. A. 2010; Melanized fungi in human disease. Clin Microbiol Rev 23:884–928 [View Article][PubMed]
    [Google Scholar]
  16. Sudhadham M., Prakitsin S., Sivichai S., Chaiyarat R., Dorrestein G. M., Menken S. B., de Hoog G. S. 2008; The neurotropic black yeast Exophiala dermatitidis has a possible origin in the tropical rain forest. Stud Mycol 61:145–155 [View Article][PubMed]
    [Google Scholar]
  17. Vitale R. G., de Hoog G. S. 2002; Molecular diversity, new species and antifungal susceptibilities in the Exophiala spinifera clade. Med Mycol 40:545–556[PubMed] [CrossRef]
    [Google Scholar]
  18. Walsh T. J., Groll A., Hiemenz J., Fleming R., Roilides E., Anaissie E. 2004; Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infect 10:Suppl. 148–66 [View Article][PubMed]
    [Google Scholar]
  19. Zeng J. S., De Hoog G. S. 2008; Exophiala spinifera and its allies: diagnostics from morphology to DNA barcoding. Med Mycol 46:193–208 [View Article][PubMed]
    [Google Scholar]
  20. Zeng J. S., Sutton D. A., Fothergill A. W., Rinaldi M. G., Harrak M. J., de Hoog G. S. 2007; Spectrum of clinically relevant Exophiala species in the United States. J Clin Microbiol 45:3713–3720 [View Article][PubMed]
    [Google Scholar]
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