1887

Abstract

The agar dilution method was used to investigate the sensitivity to pleuromutilins of 100 isolates of isolated from 63 pig farms between 1997 and 2001. In the period under investigation, MICs to both tiamulin and valnemulin increased, with differences between the periods 1997–98 and 1999–2001 being statistically significant ( < 0.001 for tiamulin and < 0.0001 for valnemulin). Between 1997 and 2001, the MIC and MIC of tiamulin increased from 0.062 and 0.25 μg ml, respectively, to 1.0 and 4.0 μg ml. Valnemulin MIC and MIC were ⩽ 0.031 μg ml in 1997 and by 2001 were respectively, 2.0 and 8.0 μg ml. The increase in MICs of tiamulin and valnemulin demonstrated in this study reflect the intensity of pleuromutilin use in the treatment of swine dysentery in the Czech Republic.

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2004-04-01
2019-08-20
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