1887

Abstract

There are three main, naturally occurring, epidemiological types of botulism: food-borne, intestinal colonization (infant botulism) and wound botulism. The neurological signs and symptoms are the same for all three epidemiological types and may include respiratory paralysis. Wound botulism is caused by growth of cells and release of toxin , is associated with traumatic wounds and abscesses and has been reported in drug users, such as those injecting heroin or sniffing cocaine. Up to the end of 1999 there were no confirmed cases of wound botulism in the UK. Between the beginning of 2000 and the end of December 2002, there were 33 clinically diagnosed cases of wound botulism in the UK and Ireland. All cases had injected heroin into muscle or by ‘skin popping'. The clinical diagnosis was confirmed by laboratory tests in 20 of these cases. Eighteen cases were caused by type A toxin and two by type B toxin.

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2004-06-01
2019-11-12
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References

  1. Anonymous ( 2000;). Wound botulism in an injecting drug user in London. Commun Dis Rep CDR Wkly 10, 177–180.
    [Google Scholar]
  2. Athwal, B. S., Gale, A. N., Brett, M. M. & Youl, B. D. ( 2001;). Wound botulism in the UK. Lancet 357, 234. 234.
    [Google Scholar]
  3. Beller, M. & Middaugh, J. P. ( 1990;). Repeated type E botulism in an Alaskan Eskimo. N Engl J Med 322, 855. 855.
    [Google Scholar]
  4. Brazier, J. S., Duerden, B. I., Hall, V., Salmon, J. E., Hood, J., Brett, M. M., McLauchlin, J. & George, R. C. ( 2002;). Isolation and identification of Clostridium spp.from infections associated with the injection of drugs: experiences of a microbiological investigation team. J Med Microbiol 51, 985–989.
    [Google Scholar]
  5. Brett, M. M. ( 1999;). Botulism in the United Kingdom. Eurosurveillance 4, 9–11.
    [Google Scholar]
  6. Burnens, A. ( 2000;). Cases of wound botulism in Switzerland. Eurosurveill Wkly 4, 203. 203.
    [Google Scholar]
  7. Cherubin, C. E. ( 1970;). Epidemiology of tetanus in narcotics addicts. N Y State J Med 70, 267–271.
    [Google Scholar]
  8. Dancer, S. J., McNair, D., Finn, P. & Kolsto, A.-B. ( 2002;). Bacillus cereus cellulitis from contaminated heroin. J Med Microbiol 51, 278–281.
    [Google Scholar]
  9. Davis, J. B., Mattman, L. H. & Wiley, M. ( 1951;). Clostridium botulinum in a fatal wound infection. JAMA 146, 646–648.[CrossRef]
    [Google Scholar]
  10. Dezfulian, M. & Bartlett, J. G. ( 1985;). Kinetics of growth and toxigenicity of Clostridium botulinum in experimental wound botulism. Infect Immun 49, 452–454.
    [Google Scholar]
  11. Griffin, P. M., Hatheway, C. L., Rosenbaum, R. B. & Sokolow, R. ( 1997;). Endogenous antibody production to botulinum toxin in an adult with intestinal colonisation botulism and underlying Crohn's disease. J Infect Dis 175, 633–637.[CrossRef]
    [Google Scholar]
  12. HPA ( 2003a;). Cluster of cases of tetanus in injecting drug users in England. Commun Dis Rep CDR Wkly 13 (47). http://www.hpa.org.uk/cdr/PDFfiles/2003/cdr4703.pdf, –637.
    [Google Scholar]
  13. HPA ( 2003b;). Clostridium histolyticum in injecting drug users in England. Commun Dis Rep CDR Wkly 13 (51). http://www.hpa.org. uk/cdr/PDFfiles/2003/cdr5103.pdf, –637.
    [Google Scholar]
  14. Hood, J., Horne, G., Baird, K. & Sweeney, G. ( 2000;). Third UK case of wound botulism in an injecting drug user. SCIEH Wkly Rep 34, 193. 193.
    [Google Scholar]
  15. Jensenius, M., Lovstad, R. Z., Dhaenens, G. & Rorvik, L. M. ( 2000;). A heroin user with a wobbly head. Lancet 356, 1160. 1160.[CrossRef]
    [Google Scholar]
  16. Jones, J. A., Salmon, J. E., Djuretic, T. & 13 other authors ( 2002;). An outbreak of serious illness and death among injecting drug users in England during 2000. J Med Microbiol 51, 978–984.
    [Google Scholar]
  17. Kimura, A. C., Higa, J. I., Levin, R. M. & Vugha, D. C. ( 2001;). Necrotising fasciitis and Clostridium sordelli among black tar heroin users. In Abstracts from the 39th Annual Meeting of the Infectious Diseases Society of America, abstract 110.
  18. Kudrow, D. B., Henry, D. A., Haake, D. A., Marshall, G. & Mathisen, G. E. ( 1988;). Botulism associated with Clostridium botulinum sinusitis after intranasal cocaine abuse. Ann Intern Med 109, 984–985.[CrossRef]
    [Google Scholar]
  19. Lund, B. M. & Peck, M. W. ( 2000;). Clostridium botulinum. In The Microbiological Safety and Quality of Food, vol. II, pp. 1057–1109. Edited by B. M. Lund, T. C. Baird-Parker & G. W. Gould. Gaithersburg, MD: Aspen Publishers.
  20. McGuigan, C. C., Penrice, G. M., Gruer, L., Ahmed, S., Goldberg, D., Black, M., Salmon, J. E. & Hood, J. ( 2002;). Lethal outbreak of infection with Clostridium novyi type A and other spore forming organisms in Scottish injecting drug users. J Med Microbiol 51, 971–977.
    [Google Scholar]
  21. Merrison, A. F. A., Chidley, K. E., Dunnett, J. & Sieradzan, K. A. ( 2002;). Wound botulism associated with subcutaneous drug use. BMJ 325, 1020–1021.[CrossRef]
    [Google Scholar]
  22. Merson, M. H. & Dowell, V. R., Jr ( 1973;). Epidemiologic, clinical and laboratory aspects of wound botulism. N Engl J Med 289, 1005–1010.[CrossRef]
    [Google Scholar]
  23. Mulleague, L., Bonner, S. M., Samuel, A., Nichols, P., Khan, M., Shaw, S. & Grüning, T. ( 2001;). Wound botulism in drug addicts in the United Kingdom. Anaesthesia 56, 120–123.[CrossRef]
    [Google Scholar]
  24. Noone, M., Tabaqchali, M. & Spillane, J. B. ( 2002;). Clostridium novyi causing necrotising fasciitis in an injecting drug user. J Clin Pathol 55, 141–142.[CrossRef]
    [Google Scholar]
  25. Passaro, D. J., Werner, S. B., McGee, J., MacKenzie, W. R. & Vugia, D. J. ( 1998;). Wound botulism associated with black tar heroin among injecting drug users. JAMA 279, 859–863.[CrossRef]
    [Google Scholar]
  26. Ringertz, S. H., Hoiby, E. A., Jensenius, M., Maehlen, J., Caugant, D. A., Myklebust, A. & Fossum, K. ( 2000;). Injectional anthrax in a heroin skin-popper. Lancet 356, 1574–1575.[CrossRef]
    [Google Scholar]
  27. Schroeder, K. & Tollosford, A. ( 1962;). Botulism from fermented trout. J Norw Med Assoc 82, 1084–1086.
    [Google Scholar]
  28. Solomon, H. M. & Lilly, T., Jr ( 1998;). Clostridium botulinum. In FDA Bacteriological Analytical Manual, 8th edn, revision A, pp. 17.01–17.10. Rockville, MD: US Food & Drug Administration.
  29. Tunkel, A. R. & Pradhan, S. K. ( 2002;). Central nervous system infections in injection drug users. Infect Dis Clin North Am 16, 589–605.[CrossRef]
    [Google Scholar]
  30. Weber, J. T., Goodpasture, H. C., Alexander, H., Weber, S. B., Hatheway, C. L. & Tauxe, R. V. ( 1993;). Wound botulism in a patient with a tooth abscess: case report and review. Clin Infect Dis 16, 635–639.[CrossRef]
    [Google Scholar]
  31. Werner, S. B., Passaro, D., McGee, J., Schechter, R. & Vugia, D. J. ( 2000;). Wound botulism in California, 1951–1998: recent epidemic in heroin injectors. Clin Infect Dis 31, 1018–1024.[CrossRef]
    [Google Scholar]
  32. Witcome, M. & Shone, C. C. ( 1998;). Botulinum neurotoxins: mode of action and detection. J Appl Microbiol 84, S87–S88.[CrossRef]
    [Google Scholar]
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