1887

Abstract

Two-hundred sequential isolates recovered from 26 immunocompromised patients with invasive aspergillosis or bronchial colonization were tested for their susceptibility to posaconazole, itraconazole, voriconazole, terbinafine and amphotericin B. Twenty-one patients were treated with amphotericin B and/or itraconazole. Antifungal susceptibilities of the isolates recovered before treatment were not significantly different from those of isolates recovered after the onset of antifungal therapy. The highest MICs were 0.125, 0.5, 0.5, 1 and 1 μg ml for posaconazole, itraconazole, voriconazole, terbinafine and amphotericin B, respectively. It is concluded that the emergence of resistance in during antifungal therapy with amphotericin B or itraconazole is an uncommon phenomenon.

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2004-02-01
2024-04-19
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