1887

Abstract

The significance of mannoprotein serum detection in 15 patients with haematological malignancies and proven (six cases) or probable (nine cases) hepatosplenic candidiasis was retrospectively evaluated. Circulating mannoprotein antigen was detected in three of six and in one of two serum samples from two patients with probable infection. The antigen was not detected in 38 serum samples of 13 (87 %) patients. Thus, in contrast to other deep-seated infections, mannoprotein is infrequently detectable during focal hepatosplenic candidiasis and does not appear to be of diagnostic value.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.05297-0
2004-02-01
2019-11-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/53/2/JM530204.html?itemId=/content/journal/jmm/10.1099/jmm.0.05297-0&mimeType=html&fmt=ahah

References

  1. Anttila, V. J., Ruutu, P., Bondestam, S., Jansson, S. E., Nordling, S., Farkkila, M., Sivonen, A., Castren, M. & Ruutu, T. ( 1994;). Hepatosplenic yeast infection in patients with acute leukemia: a diagnostic problem. Clin Infect Dis 18, 979–981.[CrossRef]
    [Google Scholar]
  2. Anttila, V. J., Elonen, E., Nordling, S., Sivonen, A., Ruutu, T. & Ruutu, P. ( 1997;). Hepatosplenic candidiasis in patients with acute leukemia: incidence and prognostic implications. Clin Infect Dis 24, 375–380.[CrossRef]
    [Google Scholar]
  3. Ascioglu, S., Rex, J. H., de Pauw, B. & 17 other authors ( 2002;). Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34, 7–14.[CrossRef]
    [Google Scholar]
  4. Cassone, A., Torosantucci, A., Boccanera, M., Pellegrini, G., Palma, C. & Malavasi, F. ( 1988;). Production and characterisation of a monoclonal antibody to a cell-surface, glucomannoprotein constituent of Candida albicans and other pathogenic Candida species. J Med Microbiol 27, 233–238.[CrossRef]
    [Google Scholar]
  5. De Bernardis, F., Girmenia, C., Boccanera, M., Adriani, D., Martino, P. & Cassone, A. ( 1993;). Use of a monoclonal antibody in a dot immunobinding assay for detection of a circulating mannoprotein of Candida spp.in neutropenic patients with invasive candidiasis. J Clin Microbiol 31, 3142–3146.
    [Google Scholar]
  6. Girmenia, C., Martino, P., De Bernardis, F. & Cassone, A. ( 1997;). Assessment of detection of Candida mannoproteinemia as a method to differentiate central venous catheter-related candidemia from invasive disease. J Clin Microbiol 35, 903–906.
    [Google Scholar]
  7. Girmenia, C., Micozzi, A., Cartoni, C., De Bernardis, F., Cassone, A. & Martino, P. ( 1999;). Detection of Candida mannoproteinemia in patients with neutropenic enterocolitis. Eur J Clin Microbiol Infect Dis 18, 55–58.[CrossRef]
    [Google Scholar]
  8. Haron, E., Feld, R., Tuffnell, P., Patterson, B., Hasselback, R. & Matlow, A. ( 1987;). Hepatic candidiasis: an increasing problem in immunocompromised patients. Am J Med 83, 17–26.
    [Google Scholar]
  9. Jones, J. M. ( 1981;). Granulomatous hepatitis due to Candida albicans in patients with acute leukemia. Ann Intern Med 94, 475–477.[CrossRef]
    [Google Scholar]
  10. Kappe, R. & Muller, J. ( 1991;). Rapid clearance of Candida albicans mannan antigens by liver and spleen in contrast to prolonged circulation of Cryptococcus neoformans antigens. J Clin Microbiol 29, 1665–1669.
    [Google Scholar]
  11. Martino, P., Venditti, M., Micozzi, A. & 8 other authors ( 1990;). Blastoschizomyces capitatus: an emerging cause of invasive fungal disease in leukemia patients. Rev Infect Dis 12, 570–582.[CrossRef]
    [Google Scholar]
  12. Pagano, L., Larocca, L. M., Marra, R., Pizzigallo, E. & Leone, G. ( 1992;). A leukemic patient with hepatosplenic abscesses due to coagulase- negative staphylococci. Clin Infect Dis 14, 364–365.[CrossRef]
    [Google Scholar]
  13. Reiss, E. & Morrison, C. J. ( 1993;). Nonculture methods for diagnosis of disseminated candidiasis. Clin Microbiol Rev 6, 311–323.
    [Google Scholar]
  14. Sendid, B., Tabouret, M., Poirot, J. L., Mathieu, D., Fruit, J. & Poulain, D. ( 1999;). New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis. J Clin Microbiol 37, 1510–1517.
    [Google Scholar]
  15. Sendid, B., Poirot, J. L., Tabouret, M., Bonnin, A., Caillot, D., Camus, D. & Poulain, D. ( 2002;). Combined detection of mannanaemia and anti-mannan antibodies as a strategy for the diagnosis of systemic infection caused by pathogenic Candida species. J Med Microbiol 51, 433–442.
    [Google Scholar]
  16. Sendid, B., Caillot, D., Baccouch-Humbert, B., Klingspor, L., Grandjean, M., Bonnin, A. & Poulain, D. ( 2003;). Contribution of the Platelia Candida-specific antibody and antigen tests to early diagnosis of systemic Candida tropicalis infection in neutropenic adults. J Clin Microbiol 41, 4551–4558.[CrossRef]
    [Google Scholar]
  17. Tashjian, L. S., Abramson, J. S. & Peacock, J. E., Jr ( 1984;). Focal hepatic candidiasis: a distinct clinical variant of candidiasis in immunocompromised patients. Rev Infect Dis 6, 689–703.[CrossRef]
    [Google Scholar]
  18. Thaler, M., Pastakia, B., Shawker, T. H., O'Leary, T. & Pizzo, P. A. ( 1988;). Hepatic candidiasis in cancer patients: the evolving picture of the syndrome. Ann Intern Med 108, 88–100.[CrossRef]
    [Google Scholar]
  19. Walsh, T. J., Hathorn, J. W., Sobel, J. D. & 12 other authors ( 1991;). Detection of circulating Candida enolase by immunoassay in patients with cancer and invasive candidiasis. N Engl J Med 324, 1026–1031.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.05297-0
Loading
/content/journal/jmm/10.1099/jmm.0.05297-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error