1887

Abstract

Pulsed-field gel electrophoresis typing was performed on a retrospective set of 129 isolates obtained over a 20 month period from 70 children admitted to, or presenting at, the Erasmus University Medical Center, Rotterdam, The Netherlands. The mean age of the children (at the end of the study) was 2.5 years, with a range of 6 months to 15 years. Fifty-one different types were isolated from the hospitalized children, with 31 % (22/70) being infected with two particularly prevalent types. These two prevalent types also exhibited different protein profiles. The majority (72%; 16/22) of the children infected with these two predominant types had spent at least 1 week on two paediatric intensive care wards. No exacerbation of existing disease or new disease was observed in children who experienced type changes.

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2003-09-01
2019-11-18
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References

  1. Bakri, F., Brauer, A. L., Sethi, S. & Murphy, T. F. ( 2002;). Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease. J Infect Dis 185, 632–640.[CrossRef]
    [Google Scholar]
  2. Cook, P. P., Hecht, D. W. & Snydman, D. R. ( 1989;). Nosocomial Branhamella catarrhalis in a paediatric intensive care unit: risk factors for disease. J Hosp Infect 13, 299–307.[CrossRef]
    [Google Scholar]
  3. Denamur, E., Suermondt, G., Debroca, A., Defouilloy, C., Laurans, G., Muir, J. F. & Orfila, J. ( 1989;). Nosocomial pulmonary infections caused by Branhamella catarrhalis in intensive care units. Agressologie 30, 251–253 (in French).
    [Google Scholar]
  4. Faden, H. ( 1995;). Comparison of the local immune response to nontypable Haemophilus influenzae (nHI) and Moraxella catarrhalis (MC) during otitis media. Adv Exp Med Biol 371B, 733–736.
    [Google Scholar]
  5. Faden, H., Harabuchi, Y. & Hong, J. J. ( 1994;). Epidemiology of Moraxella catarrhalis in children during the first 2 years of life: relationship to otitis media. J Infect Dis 169, 1312–1317.[CrossRef]
    [Google Scholar]
  6. Faden, H., Duffy, L., Wasielewski, R., Wolf, J., Krystofik, D. & Tung, Y. ( 1997;). Relationship between nasopharyngeal colonization and the development of otitis media in children.Tonawanda/Williamsville Pediatrics. J Infect Dis 175, 1440–1445.[CrossRef]
    [Google Scholar]
  7. Fagon, J. Y., Chastre, J., Hance, A. J., Montravers, P., Novara, A. & Gibert, C. ( 1993;). Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94, 281–288.[CrossRef]
    [Google Scholar]
  8. Finegold, S. M., Flynn, M. J., Rose, F. V., Jousimies-Somer, H., Jakielaszek, C., McTeague, M., Wexler, H. M., Berkowitz, E. & Wynne, B. ( 2002;). Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Clin Infect Dis 35, 428–433.[CrossRef]
    [Google Scholar]
  9. Gagneur, A., Legrand, M. C., Picard, B., Baron, R., Talbot, P. J., de Parscau, L. & Sizun, J. ( 2002a;). Nosocomial infections due to human coronaviruses in the newborn. Arch Pediatr 9, 61–69 (in French).[CrossRef]
    [Google Scholar]
  10. Gagneur, A., Sizun, J., Vallet, S., Legr, M. C., Picard, B. & Talbot, P. J. ( 2002b;). Coronavirus-related nosocomial viral respiratory infections in a neonatal and paediatric intensive care unit: a prospective study. J Hosp Infect 51, 59–64.[CrossRef]
    [Google Scholar]
  11. Hays, J. P., van der Schee, C., Loogman, A., Eadie, K., Verduin, C., Faden, H., Verbrugh, H. & van Belkum, A. ( 2003;). Total genome polymorphism and low frequency of intra-genomic variation in the uspA1 and uspA2 genes of Moraxella catarrhalis in otitis prone and non-prone children up to 2 years of age.Consequences for vaccine design? Vaccine 21, 1118–1124.[CrossRef]
    [Google Scholar]
  12. Ikram, R. B., Nixon, M., Aitken, J. & Wells, E. ( 1993;). A prospective study of isolation of Moraxella catarrhalis in a hospital during the winter months. J Hosp Infect 25, 7–14.[CrossRef]
    [Google Scholar]
  13. Kasian, G. F., Shafran, S. D. & Shyleyko, E. M. ( 1989;). Branhamella catarrhalis bronchopulmonary isolates in PICU patients. Pediatr Pulmonol 7, 128–132.[CrossRef]
    [Google Scholar]
  14. Lode, H., Raffenberg, M., Erbes, R., Geerdes-Fenge, H. & Mauch, H. ( 2000;). Nosocomial pneumonia: epidemiology, pathogenesis, diagnosis, treatment and prevention. Curr Opin Infect Dis 13, 377–384.[CrossRef]
    [Google Scholar]
  15. Martinez, G., Ahmed, K., Zheng, C. H., Watanabe, K., Oishi, K. & Nagatake, T. ( 1999;). DNA restriction patterns produced by pulsed-field gel electrophoresis in Moraxella catarrhalis isolated from different geographical areas. Epidemiol Infect 122, 417–422.[CrossRef]
    [Google Scholar]
  16. Morgan, M. G., McKenzie, H., Enright, M. C., Bain, M. & Emmanuel, F. X. ( 1992;). Use of molecular methods to characterize Moraxella catarrhalis strains in a suspected outbreak of nosocomial infection. Eur J Clin Microbiol Infect Dis 11, 305–312.[CrossRef]
    [Google Scholar]
  17. Patterson, T. F., Patterson, J. E., Masecar, B. L., Barden, G. E., Hierholzer, W. J., Jr & Zervos, M. J. ( 1988;). A nosocomial outbreak of Branhamella catarrhalis confirmed by restriction endonuclease analysis. J Infect Dis 157, 996–1001.[CrossRef]
    [Google Scholar]
  18. Pfaller, M. A., Ehrhardt, A. F. & Jones, R. N. ( 2001;). Frequency of pathogen occurrence and antimicrobial susceptibility among community-acquired respiratory tract infections in the respiratory surveillance program study: microbiology from the medical office practice environment. Am J Med 111 (Suppl. 9A), 4S–12S.[CrossRef]
    [Google Scholar]
  19. Richards, S. J., Greening, A. P., Enright, M. C., Morgan, M. G. & McKenzie, H. ( 1993;). Outbreak of Moraxella catarrhalis in a respiratory unit. Thorax 48, 91–92.[CrossRef]
    [Google Scholar]
  20. Sethi, S. & Murphy, T. F. ( 2001;). Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev 14, 336–363.[CrossRef]
    [Google Scholar]
  21. Sethi, S., Evans, N., Grant, B. J. & Murphy, T. F. ( 2002;). New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 347, 465–471.[CrossRef]
    [Google Scholar]
  22. van Alphen, L., Jansen, H. M. & Dankert, J. ( 1995;). Virulence factors in the colonization and persistence of bacteria in the airways. Am J Respir Crit Care Med 151, 2094–2099.[CrossRef]
    [Google Scholar]
  23. Verduin, C. M., Kools-Sijmons, M., van der Plas, J., Vlooswijk, J., Tromp, M., van Dijk, H., Banks, J., Verbrugh, H. & van Belkum, A. ( 2000;). Complement-resistant Moraxella catarrhalis forms a genetically distinct lineage within the species. FEMS Microbiol Lett 184, 1–8.[CrossRef]
    [Google Scholar]
  24. Verduin, C. M., Hol, C., Fleer, A., van Dijk, H. & van Belkum, A. ( 2002;). Moraxella catarrhalis: from emerging to established pathogen. Clin Microbiol Rev 15, 125–144.[CrossRef]
    [Google Scholar]
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