What makes resistance to methicillin heterogeneous?

References

1. Berger-Bächi, B. & Rohrer, S. ( 2002;). Factors influencing methicillin resistance in staphylococci. Arch Microbiol 178, 165–171.[CrossRef]
   [Google Scholar]
2. Boyce, J. M., Medeiros, A. A., Papa, E. F. & O'Gara, C. J. ( 1990;). Induction of beta-lactamase and methicillin resistance in unusual strains of methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 25, 73–81.
   [Google Scholar]
3. Brandenberger, M., Tschierske, M., Giachino, P., Wada, A. & Berger-Bächi, B. ( 2000;). Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases teicoplanin resistance in Staphylococcus aureus. Biochim Biophys Acta 1523, 135–139.[CrossRef]
   [Google Scholar]
4. CDC ( 2002;). Staphylococcus aureus resistant to vancomycin – United States, 2002. MMWR (Morb Mortal Wkly Rep) 51, 565–567.
   [Google Scholar]
5. Chambers, H. F. & Hackbarth, C. J. ( 1987;). Effect of NaCl and nafcillin on penicillin-binding protein 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 31, 1982–1988.[CrossRef]
   [Google Scholar]
6. de Lencastre, H., Figueiredo, A. M. S. & Tomasz, A. ( 1993;). Genetic control of population structure in heterogeneous strains of methicillin resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 12, 13–18.[CrossRef]
   [Google Scholar]
7. Domanski, T. L. & Bayles, K. W. ( 1995;). Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter. Gene 167, 111–113.[CrossRef]
   [Google Scholar]
8. Domanski, T. L., de Jonge, B. L. & Bayles, K. W. ( 1997;). Transcription analysis of the Staphylococcus aureus gene encoding penicillin-binding protein 4. J Bacteriol 179, 2651–2657.
   [Google Scholar]
9. Finan, J. E., Rosato, A. E., Dickinson, T. M., Ko, D. & Archer, G. L. ( 2002;). Conversion of oxacillin-resistant staphylococci from heterotypic to homotypic resistance expression. Antimicrob Agents Chemother 46, 24–30.[CrossRef]
   [Google Scholar]
10. Giesbrecht, P., Kersten, T., Maidhof, H. & Wecke, J. ( 1998;). Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin. Microbiol Mol Biol Rev 62, 1371–1414.
    [Google Scholar]
11. Goessens, W. H., Wouters, J. T., Fontijne, P. & Michel, M. F. ( 1986;). Cell-bound and extracellular autolytic activity of a tolerant and a nontolerant Staphylococcus aureus strain exposed to methicillin. J Antimicrob Chemother 18, 459–466.[CrossRef]
    [Google Scholar]
12. Groicher, K. H., Firek, B. A., Fujimoto, D. F. & Bayles, K. W. ( 2000;). The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance. J Bacteriol 182, 1794–1801.[CrossRef]
    [Google Scholar]
13. Gustafson, J. E. & Wilkinson, B. J. ( 1989;). Lower autolytic activity in a homogeneous methicillin-resistant Staphylococcus aureus strain compared to derived heterogeneous-resistant and susceptible strains. FEMS Microbiol Lett 50, 107–111.
    [Google Scholar]
14. Hackbarth, C. J., Miick, C. & Chambers, H. F. ( 1994;). Altered production of penicillin-binding protein 2a can affect phenotypic expression of methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 38, 2568–2571.[CrossRef]
    [Google Scholar]
15. Hiramatsu, K., Asada, K., Suzuki, E., Okonogi, K. & Yokota, T. ( 1992;). Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Lett 298, 133–136.[CrossRef]
    [Google Scholar]
16. Ito, T., Katayama, Y. & Hiramatsu, K. ( 1999;). Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrob Agents Chemother 43, 1449–1458.
    [Google Scholar]
17. Maki, H. & Murakami, K. ( 1997;). Formation of potent hybrid promoters of the mutant llm gene by IS256 transposition in methicillin-resistant Staphylococcus aureus. J Bacteriol 179, 6944–6948.
    [Google Scholar]
18. Maki, H., Yamaguchi, T. & Murakami, K. ( 1994;). Cloning and characterization of a gene affecting the methicillin resistance level and the autolysis rate in Staphylococcus aureus. J Bacteriol 176, 4993–5000.
    [Google Scholar]
19. Matthews, P. R. & Stewart, P. R. ( 1984;). Resistance heterogeneity in methicillin-resistant Staphylococcus aureus. FEMS Microbiol Lett 22, 161–166.[CrossRef]
    [Google Scholar]
20. McKinney, T. K., Sharma, V. K., Craig, W. A. & Archer, G. L. ( 2001;). Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and beta-lactamase regulators. J Bacteriol 183, 6862–6868.[CrossRef]
    [Google Scholar]
21. O'Brien, M. J., Kuhl, S. A. & Starzyk, M. J. ( 1995;). Correlation of teichoic acid d-alanyl esterification with the expression of methicillin resistance in Staphylococcus aureus. Microbios 83, 119–137.
    [Google Scholar]
22. Okuma, K., Iwakawa, K., Turnidge, J. D. & 10 other authors ( 2002;). Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 40, 4289–4294.[CrossRef]
    [Google Scholar]
23. Peschel, A., Vuong, C., Otto, M. & Gotz, F. ( 2000;). The d-alanine residues of Staphylococcus aureus teichoic acids alter the susceptibility to vancomycin and the activity of autolytic enzymes. Antimicrob Agents Chemother 44, 2845–2847.[CrossRef]
    [Google Scholar]
24. Schrader-Fischer, G. & Berger-Bächi, B. ( 2001;). The AbcA transporter of Staphylococcus aureus affects cell autolysis. Antimicrob Agents Chemother 45, 407–412.[CrossRef]
    [Google Scholar]
25. Sieradzki, K. & Tomasz, A. ( 1997;). Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus. J Bacteriol 179, 2557–2566.
    [Google Scholar]
26. Simpson, A. E., Skurray, R. A. & Firth, N. ( 2000;). An IS257-derived hybrid promoter directs transcription of a tetA(K) tetracycline resistance gene in the Staphylococcus aureus chromosomal mec region. J Bacteriol 182, 3345–3352.[CrossRef]
    [Google Scholar]
27. Singh, V. K., Jayaswal, R. K. & Wilkinson, B. J. ( 2001;). Cell wall-active antibiotic induced proteins of Staphylococcus aureus identified using a proteomic approach. FEMS Microbiol Lett 199, 79–84.
    [Google Scholar]
28. Sugai, M. ( 1997;). Peptidoglycan hydrolases of the staphylococci. J Infect Chemother 3, 113–127.[CrossRef]
    [Google Scholar]
29. Sugai, M., Yamada, S., Nakashima, S., Komatsuzawa, H., Matsumoto, A., Oshida, T. & Suginaka, H. ( 1997;). Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus. J Bacteriol 179, 2958–2962.
    [Google Scholar]
30. Tomasz, A., Nachman, S. & Leaf, H. ( 1991;). Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci. Antimicrob Agents Chemother 35, 124–129.[CrossRef]
    [Google Scholar]
31. Ziebuhr, W., Krimmer, V., Rachid, S., Lossner, I., Gotz, F. & Hacker, J. ( 1999;). A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Mol Microbiol 32, 345–356.[CrossRef]
    [Google Scholar]