1887

Abstract

The protein NapA has been identified as a homologue of the protein Dps. It is shown in this study that, like Dps, NapA is produced maximally in stationary phase cells and contributes to the ability of to survive under oxidative stress conditions. Moreover, NapA co-localizes with the nuclear material, suggesting that it can interact with DNA . Furthermore, it is demonstrated that repression of NapA production by iron starvation was not so pronounced in a mutant, suggesting that the ferric uptake regulator (Fur) is involved in regulation, and a potential box by which this control could be mediated is identified. This finding is consistent with the regulation of iron-binding proteins by Fur and also the modulation of Fur during oxidative stress, thus allowing NapA levels to be increased in the environmental conditions under which its ability to protect DNA from attack by toxic free radicals is most beneficial to the cell.

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2003-06-01
2024-03-29
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