1887

Abstract

Traditionally, the identification, epidemiology and spectrum of clinical diseases caused by and are dependent upon their phenotypic characterization. During a 6-year period (July 1995–June 2001), seven and two α-haemolytic streptococci were identified as and , respectively, by 16S rRNA gene sequencing. Three patients with haematological malignancies and neutropenic fever had primary bacteraemia. Three patients with valvular problems or congenital heart disease had infective endocarditis. A patient with ischemic heart disease and cerebrovascular accident had infected aortic atheroma with dissection. A patient with recurrent pyogenic cholangitis had acute cholangitis and a patient with polypoid cystitis and benign prostatic hypertrophy had acute prostatitis. Four of the nine patients died, including all three with infective endocarditis or infected atheroma. For the seven isolates, the API 20 STREP system successfully identified one and five isolates as with >95 % and 80–90 % confidence, respectively, whereas the Vitek System (GPI) and ATB Expression system (ID32 STREP) successfully identified none and one isolate as . Of the two isolates, none of the three systems successfully identified either of them as . 16S rRNA gene sequencing is the technique of choice for identifying and , and early surgical intervention should be considered when endocarditis is diagnosed.

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2003-02-01
2019-10-16
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