1887

Abstract

The relationship between chronic (formerly ) infection and lung carcinoma was investigated. A total of 123 patients who were smokers and diagnosed with lung carcinoma based on clinical and laboratory (radiological, cytological) findings were examined. Of these patients, 70 had small-cell, 28 squamous-cell and seven large-cell carcinomas, while 18 had adenocarcinoma. A total of 123 healthy persons matching patients in age, sex, duration of smoking and locality were chosen as controls. Blood samples (5 ml) were withdrawn at the time of diagnosis and 1 month later. The values between IgG ⩾ 512 and IgA ⩾ 40 were set as the criteria for chronic infections. In male patients with lung carcinoma, IgG antibody titres of ⩾ 512 and IgA antibody titres of ⩾ 40 were found at a higher rate than in the control group. This ratio was not significant for the female patients. In chronic infections, antibody titres with values IgG ⩾ 512 and IgA ⩾ 40 were found in a total of 62 (50.4 %) cases. Chronic infections were seen statistically more often in male patients with carcinoma who were aged 55 years or younger. This study supports the idea that chronic infection increases the risk of lung carcinoma.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.04845-0
2003-08-01
2019-10-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/52/8/JM520819.html?itemId=/content/journal/jmm/10.1099/jmm.0.04845-0&mimeType=html&fmt=ahah

References

  1. Anttila, T. I., Lehtinen, T., Leinonen, M., Bloigu, A., Koskela, P., Lehtinen, M. & Saikku, P. ( 1998;). Serological evidence of an association between chlamydial infections and malignant lymphomas. Br J Haematol 103, 150–156.[CrossRef]
    [Google Scholar]
  2. Arat, A., Kocazeybek, B., Enar, R., Orhon, R. & Pehlivanoğlu, S. ( 1999;). Chlamydia pneumoniae kararlı Anjina Pektoris ilişkisi. 15. Ulusal Kardiyoloji Kongresi 9–12 Ekim 1999 I2zmir 362.
  3. Blasi, F., Rizzato, G., Gambacorta, M. & 8 other authors ( 1997;). Failure to detect the presence of Chlamydia pneumoniae in sarcoid pathology specimens. Eur Respir J 10, 2609–2611.[CrossRef]
    [Google Scholar]
  4. Everett, K. D. E., Bush, R. M. & Andersen, A. A. ( 1999;). Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam.nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms. Int J Syst Evol Microbiol 49, 415–440.
    [Google Scholar]
  5. Fan, T., Lu, H., Hu, H., Shi, L., McClarty, G. A., Nance, D. M., Greenberg, A. H. & Zhong, G. ( 1998;). Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187, 487–496.[CrossRef]
    [Google Scholar]
  6. Forsey, T., Darougar, S. & Treharne, J. D. ( 1986;). Prevalence in human beings of antibodies to Chlamydia IOL-207, an atypical strain of chlamydia. J Infect 12, 145–152.[CrossRef]
    [Google Scholar]
  7. Gaydos, C. A., Fowler, C. L., Gill, V. J., Eiden, J. J. & Quinn, T. C. ( 1993;). Detection of Chlamydia pneumoniae by polymerase chain reaction-enzyme immunoassay in an immunocompromised population. Clin Infect Dis 17, 718–723.[CrossRef]
    [Google Scholar]
  8. Grayston, J. T. ( 1989;). Chlamydia pneumoniae strain TWAR. Chest 95, 664–669.[CrossRef]
    [Google Scholar]
  9. Grayston, J. T. ( 1994;). Chlamydia pneumoniae (TWAR) infections in children. Pediatr Infect Dis J 13, 675–684.[CrossRef]
    [Google Scholar]
  10. Grayston, J. T., Wang, S. P., Kuo, C. C. & Campbell, L. A. ( 1989;). Current knowledge on Chlamydia pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases. Eur J Clin Microbiol Infect Dis 8, 191–202.[CrossRef]
    [Google Scholar]
  11. Grayston, J. T., Campbell, L. A., Kuo, C. C., Mordhorst, C. H., Saikku, P., Thom, D. H. & Wang, S. P. ( 1990;). A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 161, 618–625.[CrossRef]
    [Google Scholar]
  12. Grayston, J. T., Kuo, C. C., Campbell, L. A. & Benditt, E. P. ( 1993;). Chlamydia pneumoniae, strain TWAR and atherosclerosis. Eur Heart J 14 (Suppl.), 66–71.
    [Google Scholar]
  13. Jackson, L. A., Wang, S. P., Nazar-Stewart, V., Grayston, J. T. & Vaughan, T. L. ( 2000;). Association of Chlamydia pneumoniae immunoglobulin A seropositivity and risk of lung cancer. Cancer Epidemiol Biomark Prev 9, 1263–1266.
    [Google Scholar]
  14. Karvonen, M., Tuomilehto, J., Pitkaniemi, J., Naukkarinen, A. & Saikku, P. ( 1994;). Importance of smoking for Chlamydia pneumoniae seropositivity. Int J Epidemiol 23, 1315–1321.[CrossRef]
    [Google Scholar]
  15. Kol, A., Sukhova, G. K., Lichtman, A. H. & Libby, P. ( 1998;). Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98, 300–307.[CrossRef]
    [Google Scholar]
  16. Koyi, H., Branden, E., Gnarpa, J., Gnarpe, H., Arnholm, B. & Hillerdal, G. ( 1999;). Chlamydia pneumoniae may be associated with lung cancer.Preliminary report on a seroepidemiological study. APMIS 107, 828–832.[CrossRef]
    [Google Scholar]
  17. Kuo, C. C., Shor, A., Campbell, L. A., Fukushi, H., Patton, D. L. & Grayston, J. T. ( 1993;). Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries. J Infect Dis 167, 841–849.[CrossRef]
    [Google Scholar]
  18. Laurila, A. L., Anttila, T., Laara, E., Bloigu, A., Virtamo, J., Albanes, D., Leinonen, M. & Saikku, P. ( 1997a;). Serological evidence of an association between Chlamydia pneumoniae infection and lung cancer. Int J Cancer 74, 31–34.[CrossRef]
    [Google Scholar]
  19. Laurila, A. L., Von Hertzen, L. & Saikku, P. ( 1997b;). Chlamydia pneumoniae and chronic lung diseases. Scand J Infect Dis Suppl 104, 34–36.
    [Google Scholar]
  20. Leinonen, M., Syrjala, H., Kujala, P. & Saikku, P. ( 1991;). Serological diagnosis of C. pneumoniae in adults. In Abstracts of 31st ICAAC, Chicago, Illinois, 29 September–2 October 1991, p. 209. Washington, DC: American Society for Microbiology.
  21. Maass, M., Bartels, C., Engel, P. M., Mamat, U. & Sievers, H. H. ( 1998;). Endovascular presence of viable Chlamydia pneumoniae is a common phenomenon in coronary artery disease. J Am Coll Cardiol 31, 827–832.[CrossRef]
    [Google Scholar]
  22. Moazed, T. C., Kuo, C., Patton, D. L., Grayston, J. T. & Campbell, L. A. ( 1996;). Experimental rabbit models of Chlamydia pneumoniae infection. Am J Pathol 148, 667–676.
    [Google Scholar]
  23. Moazed, T. C., Kuo, C., Grayston, J. T. & Campbell, L. A. ( 1997;). Murine models of Chlamydia pneumoniae infection and atherosclerosis. J Infect Dis 175, 883–890.[CrossRef]
    [Google Scholar]
  24. Ohshima, H. & Bartsch, H. ( 1994;). Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 305, 253–264.[CrossRef]
    [Google Scholar]
  25. Redecke, V., Dalhoff, K., Bohnet, S., Braun, J. & Maass, M. ( 1998;). Interaction of Chlamydia pneumoniae and human alveolar macrophages: infection and inflammatory response. Am J Respir Cell Mol Biol 5, 721–727.
    [Google Scholar]
  26. Saikku, P. ( 1992;). The epidemiology and significance of Chlamydia pneumoniae. J Infect 25 (Suppl.), 27–34.[CrossRef]
    [Google Scholar]
  27. Saikku, P. ( 1993;). Chlamydia pneumoniae infection as a risk factor in acute myocardial infarction. Eur Heart J 14 (Suppl.), 62–65.[CrossRef]
    [Google Scholar]
  28. Saikku, P., Leinonen, M., Mattila, K., Ekman, M. R., Nieminen, M. S., Makela, P. H., Huttunen, J. K. & Vaitonen, V. ( 1988;). Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet ii, 983–986.
  29. Saikku, P., Leinonen, M., Tenkanen, L., Linnanmaki, E., Ekman, M. R., Manninen, V., Manttari, M., Frick, M. H. & Huttunen, J. K. ( 1992;). Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study. Ann Intern Med 116, 273–278.[CrossRef]
    [Google Scholar]
  30. Thom, D. H. & Grayston, J. T. ( 1991;). Infections with Chlamydia pneumoniae strain TWAR. Clin Chest Med 12, 245–256.
    [Google Scholar]
  31. von Hertzen, L., Surcel, H. M., Kaprio, J., Koskenvuo, M., Bloigu, A., Leinanen, M. & Saikku, P. ( 1998;). Immune responses to of C.pneumoniae in twins in relation to gender and smoking. J Med Microbiol 47, 441–446.[CrossRef]
    [Google Scholar]
  32. Yamashita, K., Ouchi, K., Shirai, M., Gondo, T., Nakazawa, T. & Ito, H. ( 1998;). Distribution of Chlamydia pneumoniae infection in the atherosclerotic carotid artery. Stroke 29, 773–778.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.04845-0
Loading
/content/journal/jmm/10.1099/jmm.0.04845-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error