1887

Abstract

Multiplex PCR was used to detect genes encoding selected virulence determinants associated with strains of with K1 antigen (K1) and non-K1 (K1). The prevalence of the , , , , and genes was studied for 134 (67 K1 and 67 K1) strains isolated from pregnant women and neonates. The gene was present in 83.6 % of K1 and in 86.6 % of K1 strains. The gene was present in all tested K1 strains and in 97.0 % of non-K1 strains. K1 strains were significantly more likely to possess the following genes than K1 strains: (37.3 vs 16.4 %,  = 0.006), (35.8 vs 4.5 %, <0.001), (82.1 vs 35.8 %, <0.001) and (28.4 vs 6.0 %, <0.001). In conclusion, K1 seems to be more virulent than K1 strains in developing severe infections, thereby increasing possible sepsis or neonatal bacterial meningitis.

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2012-10-01
2020-01-26
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