1887

Abstract

Seventeen meticillin-resistant coagulase-negative staphylococci (MRCoNS), including ten , four , two and one , and an isolate with various levels of linezolid resistance were isolated from intensive care units in a Chinese hospital. PFGE indicated that the four isolates belonged to a clonal strain, and that nine of the isolates were indistinguishable (clone A1) and the other one was closely related (clone A2). A G2576T mutation was identified in domain V of the 23S rRNA gene in the isolate. Besides the G2576T mutation, a novel C2104T mutation was detected in the nine clone A1 isolates. The gene was detected in all the staphylococci except an isolate, whose 23S rRNA gene contained the G2576T mutation. There was a clonal dissemination of linezolid-resistant MRCoNS in intensive care units of our hospital, and this is the first report, to our knowledge, of linezolid-resistant staphylococci and enterococci in China.

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2012-11-01
2024-03-29
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