1887

Abstract

Outbreaks caused by producing carbapenemases and other β-lactamases have been reported. Four neonates admitted to a neonatal intensive care unit (NICU) in a Chinese hospital developed respiratory infection while receiving intensive care. In all four cases, multidrug-resistant was isolated from multiple respiratory specimens, leading to additional characterization of these organisms and investigation of the local environment in the NICU. Multiple β-lactamase genes, including , , and , as well as the quinolone resistance gene , were harboured by transferable plasmids from all four clinical isolates. Furthermore, PFGE confirmed that three of the four clinical isolates from the patients and three isolates collected from the hands of health-care workers and an incubator in the NICU belonged to the same PFGE cluster, indicating that an outbreak due to multidrug-resistant carrying and occurred in this NICU. As far as is known, this is the first report of the co-existence of and in the same isolate. These data suggest that additional precautions are needed to prevent outbreaks of infection caused by multidrug-resistant resulting from environmental exposure in NICUs.

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2012-07-01
2020-01-22
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