1887

Abstract

The aim of this study was to explore the epidemiological and molecular characteristics of in children from different cities in mainland China who were diagnosed with scarlet fever, impetigo and pharyngitis, as well as to detect asymptomatic carriers, between 2005 and 2008, and to compare the results with isolates from rural Chinese children with acute glomerulonephritis in 2005 and in the 1990s. Susceptibility tests to determine MICs and analysis of the presence of erythromycin-resistant genes (, and ) and gene typing were performed on 466 isolates from Beijing, Shanghai, Chongqing and Shenzhen. Superantigen genes ( and ) were examined by performing PCR on isolates with the most prevalent genotype. All isolates were sensitive to penicillin, cefradine and ofloxacin. The highest rate of resistance was against clarithromycin (98.1 %), followed by erythromycin (97.6 %), azithromycin and clindamycin (both 97.2 %), and tetracycline (94.0 %). Among the 466 isolates, 421 (90.3 %) harboured the gene, 145 (31.1 %) were positive and 273 (58.6 %) were positive. The gene was common in (88.8 %) and (83.3 %) genotypes. The gene was frequently observed in (90.0 %), (69.6 %), (66.7 %), (75.9 %) and (80.0 %) genotypes. The most prevalent genotypes in mainland China in recent years were and . All isolates remained sensitive to β-lactams and quinolone.

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2012-07-01
2019-12-13
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