1887

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Volume 61, Issue 6

Diarrhoeagenic as a predominant cause of paediatric nosocomial diarrhoea in India Free

Abstract

Intestinal nosocomial infections remain a major concern in paediatric wards leading to increased morbidity and mortality. This study determined the aetiological and epidemiological profile of nosocomial diarrhoea (ND) among children admitted to a hospital in India. During the period of January 2008 to June 2009, we consecutively enrolled 100 children between the age of 2 months and 14 years who developed ND as defined by the Centers for Disease Control and Prevention. A control group of patients matched for age and severity score but with no diarrhoea at admission or during their hospital stay ( = 50) were also enrolled. Stool samples were cultured for various pathogens using standard protocols. toxins and rotavirus antigen were detected using commercial ELISAs. Detection of diarrhoeagenic was carried out by multiplex PCR assay. All patient details were noted. In this study, males predominated (77 %), and 56 % children were <1 year of age and 96 % were <5 years. The mean duration of diarrhoea and hospitalization in the case group was 3.2 days and 27.5 days, respectively. Malignancy and nasogastric tube usage were significant underlying factors for the development of ND. Diarrhoeagenic was the commonest agent (47 %: enterotoxigenic , enteroaggregative and enteropathogenic were isolated in 22, 18 and 7 % of patients, respectively). toxin was seen in 9 % of cases, whilst rotavirus was found in 8 % of cases. Although rotavirus and are major causative agents of hospital-acquired diarrhoea in the developed world, in this setting diarrhoeagenic was responsible for the majority of cases of hospital-acquired diarrhoea. ND was most common in children aged <5 years.

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© 2012 SGM
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2012-06-01
2024-10-13
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Diarrhoeagenic Escherichia coli as a predominant cause of paediatric nosocomial diarrhoea in India
J. Med. Microbiol. 61, 830 (2012); https://doi.org/10.1099/jmm.0.041848-0
/content/journal/jmm/10.1099/jmm.0.041848-0
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