1887

Abstract

Data correlating β-lactamases found in commensal of human and animal origin are limited. In this study, 447 commensal isolates from the faeces of humans and swine (280 human isolates from four hospitals and 167 swine isolates from seven farms) were collected between September 2006 and January 2009 in western China. For extended-spectrum β-lactamase (ESBL)-producing and other cephalosporin-resistant isolates, the relevant β-lactamase genes ( , , group, and ) were detected by PCR analysis. Of the 447 isolates tested, 120 (26.8 %) were confirmed as producing ESBL. Among these, 70 and 40 human isolates carried a member of the group (13 , 21 , four , eight , four , 15 and five ) or (14 , seven , ten , five and four ),respectively, whilst six and four swine isolates carried a member of the group (one and five ) or (three and one ), respectively. Furthermore, 59 human and swine isolates and seven human isolates carried and , respectively. These findings indicate that the group, including the novel variant , and are the predominant ESBL genes in both humans and swine in western China, and is also common in both groups. The carriage rates of broad-spectrum β-lactamases among commensal was much lower in swine than in humans, suggesting that β-lactamase genes have not established themselves in animal ecosystems in western China.

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2012-02-01
2020-01-26
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