1887

Abstract

KFRI342, isolated from the Korean traditional food kimchi, was investigated for its suitability as a dietary probiotic. The effects of KFRI342 on the development of chemically induced (1,2-dimethylhydrazine; DMH) precancerous cytological changes of the colon were investigated in rats. Forty-five male F344 rats were randomly divided into three dietary groups. The control group received a high-fat diet (HF), a second group received a high-fat diet containing the carcinogen (HFC), and a final group received a high-fat diet containing the carcinogen and KFRI342 (HFCL). KFRI342 was administered orally three times per week at 2×10 c.f.u. ml. KFRI342 treatments decreased the number of in faecal samples, the enzyme activities of β-glucuronidase and β-glucosidase, and plasma triglyceride concentration compared to the HF and HFC treatments (<0.05). KFRI342 consumption also decreased the ratio of aberrant crypts to aberrant crypt foci incidence and the number of aberrant crypts in HFCL rats. Therefore, showed potential probiotic activity as an inhibitor of DMH-induced symptoms in live rats. Our studies indicate that from kimchi may be suitable as a probiotic for human use.

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2012-03-01
2019-10-20
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