1887

Journal of Medical Microbiology logo

Volume 61, Issue 3

Effect of KFRI342 on the development of chemically induced precancerous growths in the rat colon Free

Abstract

KFRI342, isolated from the Korean traditional food kimchi, was investigated for its suitability as a dietary probiotic. The effects of KFRI342 on the development of chemically induced (1,2-dimethylhydrazine; DMH) precancerous cytological changes of the colon were investigated in rats. Forty-five male F344 rats were randomly divided into three dietary groups. The control group received a high-fat diet (HF), a second group received a high-fat diet containing the carcinogen (HFC), and a final group received a high-fat diet containing the carcinogen and KFRI342 (HFCL). KFRI342 was administered orally three times per week at 2×10 c.f.u. ml. KFRI342 treatments decreased the number of in faecal samples, the enzyme activities of β-glucuronidase and β-glucosidase, and plasma triglyceride concentration compared to the HF and HFC treatments (<0.05). KFRI342 consumption also decreased the ratio of aberrant crypts to aberrant crypt foci incidence and the number of aberrant crypts in HFCL rats. Therefore, showed potential probiotic activity as an inhibitor of DMH-induced symptoms in live rats. Our studies indicate that from kimchi may be suitable as a probiotic for human use.

  • Received:
  • Accepted:
  • Published Online:
© 2012 SGM
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.035154-0
2012-03-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jmm/61/3/361.html?itemId=/content/journal/jmm/10.1099/jmm.0.035154-0&mimeType=html&fmt=ahah

References

  1. Alves de Lima R. O., Bazo A. P., Salvadori D. M., Rech C. M., de Palma Oliveira D., de Aragão Umbuzeiro G. 2007; Mutagenic and carcinogenic potential of a textile azo dye processing plant effluent that impacts a drinking water source. Mutat Res 626:53–60[PubMed] [CrossRef]
     [Google Scholar]
  2. Benno Y., Mitsuoka T. 1992; Impact of Bifidobacterium longum on human fecal microflora. Microbiol Immunol 36:683–694[PubMed] [CrossRef]
     [Google Scholar]
  3. Bird R. P. 1987; Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37:147–151 [View Article][PubMed]
     [Google Scholar]
  4. Bird R. P., Good C. K. 2000; The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett 112-113:395–402 [View Article][PubMed]
     [Google Scholar]
  5. Bouhnik Y., Flourie B., Andrieux C., Bisetti N., Briet F., Rambaud J.-C. 1996; Effects of Bifidobacterium sp. fermented milk ingested with or without inulin on colonic bifidobacteria and enzymatic activities in healthy humans. Eur J Clin Nutr 50:269–273[PubMed]
     [Google Scholar]
  6. Chang J.-H., Shim Y. Y., Cha S.-K., Chee K.-M. 2010; Probiotic characteristics of lactic acid bacteria isolated from kimchi. J Appl Microbiol 109:220–230[PubMed]
     [Google Scholar]
  7. Chipman J. K. 1982; Bile as a source of potential reactive metabolites. Toxicology 25:99–111 [View Article][PubMed]
     [Google Scholar]
  8. Choudhary G., Hansen H. 1998; Human health perspective on environmental exposure to hydrazines: a review. Chemosphere 37:801–843 [View Article][PubMed]
     [Google Scholar]
  9. Commane D., Hughes R., Shortt C., Rowland I. 2005; The potential mechanisms involved in the anti-carcinogenic action of probiotics. Mutat Res 591:276–289 [View Article][PubMed]
     [Google Scholar]
  10. de Roos N. M., Katan M. B. 2000; Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998. Am J Clin Nutr 71:405–411[PubMed]
     [Google Scholar]
  11. Demarzo M. M., Garcia S. B. 2004; Exhaustive physical exercise increases the number of colonic preneoplastic lesions in untrained rats treated with a chemical carcinogen. Cancer Lett 216:31–34 [View Article][PubMed]
     [Google Scholar]
  12. Femia A. P., Luceri C., Dolara P., Giannini A., Biggeri A., Salvadori M., Clune Y., Collins K. J., Paglierani M., Caderni G. 2002; Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23:1953–1960 [View Article][PubMed]
     [Google Scholar]
  13. Fodde R. 2002; The APC gene in colorectal cancer. Eur J Cancer 38:867–871 [View Article][PubMed]
     [Google Scholar]
  14. Garófolo A., Avesani C. M., Camargo K. G., Barros M. E., Silva S. R. J., Taddei J. A. A. C., Sigulem D. M. 2004; Dieta e câncer: um enfoque epidemiológico. Rev Nutr 17:491–505 [View Article]
     [Google Scholar]
  15. George S. E., Wolf D. C., Brooks L. R., Bailey K. C., Hooth M. J., Nelson G. M. 2004; Changes in cecal microbial metabolism of rats induced by individual and a mixture of drinking water disinfection by-products. Cancer Lett 204:15–21 [View Article][PubMed]
     [Google Scholar]
  16. Giovannucci E. 2001; Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 131:Suppl.3109S–3120S[PubMed]
     [Google Scholar]
  17. Goldin B. R., Gorbach S. L. 1984; The effect of milk and Lactobacillus feeding on human intestinal bacterial enzyme activity. Am J Clin Nutr 39:756–761[PubMed]
     [Google Scholar]
  18. Goldin B. R., Gorbach S. L., Saxelin M., Barakat S., Gualtieri L., Salminen S. 1992; Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci 37:121–128 [View Article][PubMed]
     [Google Scholar]
  19. Goldin B. R., Gualtieri L. J., Moore R. P. 1996; The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer 25:197–204 [View Article][PubMed]
     [Google Scholar]
  20. Maldonado Galdeano C. M., de Moreno de LeBlanc A., Vinderola G., Bonet M. E., Perdigón G. 2007; Proposed model: mechanisms of immunomodulation induced by probiotic bacteria. Clin Vaccine Immunol 14:485–492 [View Article][PubMed]
     [Google Scholar]
  21. Mangell P., Nejdfors P., Wang M., Ahrné S., Weström B., Thorlacius H., Jeppsson B. 2002; Lactobacillus plantarum 299v inhibits Escherichia coli-induced intestinal permeability. Dig Dis Sci 47:511–516 [View Article][PubMed]
     [Google Scholar]
  22. Manus B., Adang R. P., Ambergen A. W., Brägelmann R., Armbrecht U., Stockbrügger R. W. 1997; The risk factor profile of recto-sigmoid adenomas: a prospective screening study of 665 patients in a clinical rehabilitation centre. Eur J Cancer Prev 6:38–43 [View Article][PubMed]
     [Google Scholar]
  23. McKeown-Eyssen G. 1994; Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?. Cancer Epidemiol Biomarkers Prev 3:687–695[PubMed]
     [Google Scholar]
  24. Niho N., Takahashi M., Shoji Y., Takeuchi Y., Matsubara S., Sugimura T., Wakabayashi K. 2003; Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand. Cancer Sci 94:960–964 [View Article][PubMed]
     [Google Scholar]
  25. Onoue M., Kado S., Sakaitani Y., Uchida K., Morotomi M. 1997; Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats. Cancer Lett 113:179–186 [View Article][PubMed]
     [Google Scholar]
  26. Reddy B. S., Weisburger J. H., Wynder E. L. 1974; Fecal bacterial β-glucuronidase: control by diet. Science 183:416–417 [View Article][PubMed]
     [Google Scholar]
  27. Reddy B. S., Mangat S., Weisburger J. H., Wynder E. L. 1977; Effect of high-risk diets for colon carcinogenesis on intestinal mucosal and bacterial β-glucuronidase activity in F344 rats. Cancer Res 37:3533–3536[PubMed]
     [Google Scholar]
  28. Roberton A. M. 1993; Roles of endogenous substances and bacteria in colorectal cancer. Mutat Res 290:71–78 [CrossRef]
     [Google Scholar]
  29. Rod T. O., Midtvedt T. 1977; Origin of intestinal β-glucuronidase in germfree, monocontaminated and conventional rats. Acta Pathol Microbiol Scand [B] 85:271–276[PubMed]
     [Google Scholar]
  30. Rowland I. R., Rumney C. J., Coutts J. T., Lievense L. C. 1998; Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 19:281–285 [View Article]
     [Google Scholar]
  31. Sequeira J. L., Kobayasi S. S., Rodrigues M. A. 2000; Early and late effects of wound healing on development of colon tumours in a model of colon carcinogenesis by 1,2-dimethylhydrazine in the rat. Pathology 32:250–252[PubMed]
     [Google Scholar]
  32. Soylemez G., Brashears M. M., Smith D. A., Cuppett S. L. 2001; Microbial quality of alfalfa seeds and sprouts after a chlorine treatment and packaging modifications. J Food Sci 66:153–157 [View Article]
     [Google Scholar]
  33. Sung H.-Y., Jeong H.-J., Choi Y.-S. 2004; Effects of fructans and isomaltooligosaccharide on large bowel mass and plasma and fecal immunoglobulin A in rat. Nutr Sci 7:196–200
     [Google Scholar]
  34. Suzuki T., Itoh K., Kaneko T., Suzuki H. 1997; Inhibition of bacterial translocation from the gastrointestinal tract of mice by oral administration of a culture condensate of Bifidobacterium longum . J Vet Med Sci 59:665–669 [View Article][PubMed]
     [Google Scholar]
  35. Takayama T., Katsuki S., Takahashi Y., Ohi M., Nojiri S., Sakamaki S., Kato J., Kogawa K., Miyake H., Niitsu Y. 1998; Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 339:1277–1284 [View Article][PubMed]
     [Google Scholar]
  36. Wargovich M. J., Chen C. D., Harris C., Yang E., Velasco M. 1995; Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon. Int J Cancer 60:515–519 [View Article][PubMed]
     [Google Scholar]
  37. Yamada K., Araki S., Tamura M., Sakai I., Takahashi Y., Kashihara H., Kono S. 1998; Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. Int J Epidemiol 27:794–798 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.035154-0
Loading
Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon
J. Med. Microbiol. 61, 361 (2012); https://doi.org/10.1099/jmm.0.035154-0
/content/journal/jmm/10.1099/jmm.0.035154-0
/content/journal/jmm/10.1099/jmm.0.035154-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error