1887

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Volume 61, Issue 1

Haemophilia-associated serotype O:1 septicaemia: the role of iron Free

Abstract

Septicaemia and septic arthritis due to are rare diseases with high mortality rates. Reactive arthritis caused by infection is a well-known complication but septic arthritis is found at a much lower frequency. It has already been established that there is a relationship between yersiniosis and iron but there are currently no data about yersiniosis and haematological disorders such as haemophilia. We report a case of septic arthritis due to as an early manifestation of septicaemia in a patient with severe haemophilia A. The patient had no history of immunosuppression and presented with a repeat case of haemarthrosis with a fever of unknown origin. Furthermore, he suffered from acute-on-chronic renal failure and non-ST segment elevation myocardial infarction. Arthrocentesis and blood culture tested positive for . Iron deposits at localized sites in the synovium in patients with haemophilia have been described, and as infections are common in patients with secondary iron overload, we felt that a review of the literature was in order. Severe infection is often associated with iron overload, a condition that might occur as a side effect in the treatment of haemophilia. Iron overload, which plays an important role in the pathogenesis of haemophilic arthropathy, may have increased the virulence of in the present case.

  • Received:
  • Accepted:
  • Published Online:
© 2012 SGM
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2012-01-01
2024-04-25
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