1887

Abstract

Septicaemia and septic arthritis due to are rare diseases with high mortality rates. Reactive arthritis caused by infection is a well-known complication but septic arthritis is found at a much lower frequency. It has already been established that there is a relationship between yersiniosis and iron but there are currently no data about yersiniosis and haematological disorders such as haemophilia. We report a case of septic arthritis due to as an early manifestation of septicaemia in a patient with severe haemophilia A. The patient had no history of immunosuppression and presented with a repeat case of haemarthrosis with a fever of unknown origin. Furthermore, he suffered from acute-on-chronic renal failure and non-ST segment elevation myocardial infarction. Arthrocentesis and blood culture tested positive for . Iron deposits at localized sites in the synovium in patients with haemophilia have been described, and as infections are common in patients with secondary iron overload, we felt that a review of the literature was in order. Severe infection is often associated with iron overload, a condition that might occur as a side effect in the treatment of haemophilia. Iron overload, which plays an important role in the pathogenesis of haemophilic arthropathy, may have increased the virulence of in the present case.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.034967-0
2012-01-01
2019-10-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/61/1/157.html?itemId=/content/journal/jmm/10.1099/jmm.0.034967-0&mimeType=html&fmt=ahah

References

  1. Cantinieaux B. , Boelaert J. , Hariga C. , Fondu P. . ( 1988; ). Impaired neutrophil defence against Yersinia enterocolitica in patients with iron overload who are undergoing dialysis. . J Lab Clin Med 111:, 524–528.[PubMed]
    [Google Scholar]
  2. Chiu H. Y. , Flynn D. M. , Hoffbrand A. V. , Politis D. . ( 1986; ). Infection with Yersinia enterocolitica in patients with iron overload. . Br Med J (Clin Res Ed) 292:, 97. [CrossRef] [PubMed]
    [Google Scholar]
  3. Chol C. , Blanc P. L. , Forel C. . ( 2008; ). [Yersinia enterocolitica infection of a prosthetic knee joint]. . Med Mal Infect 38:, 403–405 (in French). [CrossRef] [PubMed]
    [Google Scholar]
  4. Cormier G. , Lucas V. , Varin S. , Hamelin J. P. , Tanguy G. . ( 2007; ). Yersinia pseudotuberculosis infection of a lumbar facet joint. . Joint Bone Spine 74:, 110–111. [CrossRef] [PubMed]
    [Google Scholar]
  5. Deacon A. G. , Hay A. , Duncan J. . ( 2003; ). Septicemia due to Yersinia pseudotuberculosis – a case report. . Clin Microbiol Infect 9:, 1118–1119. [CrossRef] [PubMed]
    [Google Scholar]
  6. Fukushima H. , Matsuda Y. , Seki R. , Tsubokura M. , Takeda N. , Shubin F. N. , Paik I. K. , Zheng X. B. . ( 2001; ). Geographical heterogeneity between Far Eastern and Western countries in prevalence of the virulence plasmid, the superantigen Yersinia pseudotuberculosis-derived mitogen, and the high-pathogenicity island among Yersinia pseudotuberculosis strains. . J Clin Microbiol 39:, 3541–3547. [CrossRef] [PubMed]
    [Google Scholar]
  7. Heesemann J. , Hantke K. , Vocke T. , Saken E. , Rakin A. , Stojiljkovic I. , Berner R. . ( 1993; ). Virulence of Yersinia enterocolitica is closely associated with siderophore production, expression of an iron-repressible outer membrane polypeptide of 65 000 Da and pesticin sensitivity. . Mol Microbiol 8:, 397–408. [CrossRef] [PubMed]
    [Google Scholar]
  8. Jalava K. , Hallanvuo S. , Nakari U. M. , Ruutu P. , Kela E. , Heinäsmäki T. , Siitonen A. , Nuorti J. P. . ( 2004; ). Multiple outbreaks of Yersinia pseudotuberculosis infections in Finland. . J Clin Microbiol 42:, 2789–2791. [CrossRef] [PubMed]
    [Google Scholar]
  9. Leclercq A. , Martin L. , Vergnes M. L. , Ounnoughene N. , Laran J. F. , Giraud P. , Carniel E. . ( 2005; ). Fatal Yersinia enterocolitica biotype 4 serovar O:3 sepsis after red blood cell transfusion. . Transfusion 45:, 814–818. [CrossRef] [PubMed]
    [Google Scholar]
  10. Lemaitre B. C. , Mazigh D. A. , Scavizzi M. R. . ( 1991; ). Failure of β-lactam antibiotics and marked efficacy of fluoroquinolones in treatment of murine Yersinia pseudotuberculosis infection. . Antimicrob Agents Chemother 35:, 1785–1790.[PubMed] [CrossRef]
    [Google Scholar]
  11. Ljungberg P. , Valtonen M. , Harjola V. P. , Kaukoranta-Tolvanen S. S. , Vaara M. . ( 1995; ). Report of four cases of Yersinia pseudotuberculosis septicemia and a literature review. . Eur J Clin Microbiol Infect Dis 14:, 804–810. [CrossRef] [PubMed]
    [Google Scholar]
  12. Ljungberg P. , Valtonen M. , Vaara M. . ( 1996; ). [Yersinia pseudotuberculosis, a rare cause of septicemia]. . Duodecim 112:, 613–618 (in Finnish).[PubMed]
    [Google Scholar]
  13. Lucier T. S. , Fetherston J. D. , Brubaker R. R. , Perry R. D. . ( 1996; ). Iron uptake and iron-repressible polypeptides in Yersinia pestis . . Infect Immun 64:, 3023–3031.[PubMed]
    [Google Scholar]
  14. Mashiba K. , Kojima T. , Ootsuka T. , Kusaba T. . ( 2008; ). [Yersinia psuedotuberculosis septicemia in a healthy young woman]. . Kansenshogaku Zasshi 82:, 86–89 (in Japanese).[PubMed] [CrossRef]
    [Google Scholar]
  15. Niskanen T. , Waldenström J. , Fredriksson-Ahomaa M. , Olsen B. , Korkeala H. . ( 2003; ). virF-positive Yersinia pseudotuberculosis and Yersinia enterocolitica found in migratory birds in Sweden. . Appl Environ Microbiol 69:, 4670–4675. [CrossRef] [PubMed]
    [Google Scholar]
  16. Nuorti J. P. , Niskanen T. , Hallanvuo S. , Mikkola J. , Kela E. , Hatakka M. , Fredriksson-Ahomaa M. , Lyytikainen O. , Siitonen A. . & other authors ( 2004; ). A widespread outbreak of Yersinia pseudotuberculosis O:3 infection from iceberg lettuce. . J Infect Dis 189:, 766–774. [CrossRef] [PubMed]
    [Google Scholar]
  17. Paglia M. G. , D’Arezzo S. , Festa A. , Del Borgo C. , Loiacono L. , Antinori A. , Antonucci G. , Visca P. . ( 2005; ). Yersinia pseudotuberculosis septicemia and HIV. . Emerg Infect Dis 11:, 1128–1130.[PubMed] [CrossRef]
    [Google Scholar]
  18. Raffini L. , Manno C. . ( 2007; ). Modern management of haemophilic arthropathy. . Br J Haematol 136:, 777–787. [CrossRef] [PubMed]
    [Google Scholar]
  19. Rathmell W. K. , Arguin P. , Chan S. , Yu A. . ( 1999; ). Yersinia pseudotuberculosis bacteremia and splenic abscess in a patient with non-insulin-dependent diabetes mellitus. . West J Med 170:, 110–112.[PubMed]
    [Google Scholar]
  20. Roosendaal G. , Vianen M. E. , Wenting M. J. , van Rinsum A. C. , van den Berg H. M. , Lafeber F. P. , Bijlsma J. W. . ( 1998; ). Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. . J Bone Joint Surg Br 80:, 540–545. [CrossRef] [PubMed]
    [Google Scholar]
  21. Schubert S. , Rakin A. , Karch H. , Carniel E. , Heesemann J. . ( 1998; ). Prevalence of the “high-pathogenicity island” of Yersinia species among Escherichia coli strains that are pathogenic to humans. . Infect Immun 66:, 480–485.[PubMed]
    [Google Scholar]
  22. Une T. , Brubaker R. R. . ( 1984; ). In vivo comparison of avirulent Vwa- and Pgm- or Pstr phenotypes of yersiniae. . Infect Immun 43:, 895–900.[PubMed]
    [Google Scholar]
  23. van Zonneveld M. , Droogh J. M. , Fieren M. W. , Gyssens I. C. , van Gelder T. , Weimar W. . ( 2002; ). Yersinia pseudotuberculosis bacteraemia in a kidney transplant patient. . Nephrol Dial Transplant 17:, 2252–2254. [CrossRef] [PubMed]
    [Google Scholar]
  24. Vincent P. , Leclercq A. , Martin L. , Duez J.-M. , Simonet M. , Carniel E. . Yersinia Surveillance Network ( 2008; ). Sudden onset of pseudotuberculosis in humans, France, 2004–05. . Emerg Infect Dis 14:, 1119–1122. [CrossRef] [PubMed]
    [Google Scholar]
  25. Wren B. W. . ( 2003; ). The yersiniae – a model genus to study the rapid evolution of bacterial pathogens. . Nat Rev Microbiol 1:, 55–64. [CrossRef] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.034967-0
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error