1887

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Volume 60, Issue 11

Loss of capsule among isolates from porcine endocarditis and its biological significance Free

Abstract

, particularly serotype 2, is a pathogen of both pigs and humans associated with a wide range of diseases, including meningitis, septicaemia and endocarditis. Among the genes in the capsular polysaccharide biosynthesis () locus, exists only in the serotype 2 and 1/2 strains; therefore, -positive strains are suspected to have capsules of serotype 2 or 1/2. Coagglutination using antiserotype 1 and antiserotype 2 sera and/or transmission electron microscopy analysis of 288 -positive isolates from pigs showed that 32 (100 %) isolates from meningitis were encapsulated, whereas 86 (34 %) of 256 isolates from endocarditis were unencapsulated, indicating that capsule loss often occurred in the isolates from endocarditis. To investigate the genetic backgrounds, we randomly selected 43 unencapsulated isolates and analysed their loci by PCR scanning. Among them, 8 and 10 isolates apparently had deletions and insertions, respectively, in loci. In addition, a representative unencapsulated isolate and an unencapsulated strain showed adherence to porcine and human platelets, a major virulence determinant for infective endocarditis, to a significantly greater extent than the encapsulated strains. Although the capsule is considered to be an important virulence factor in , these results suggest that loss of capsular production is beneficial to in the course of infective endocarditis.

  • Received:
  • Accepted:
  • Published Online:
© 2011 SGM
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2011-11-01
2024-04-25
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Loss of capsule among Streptococcus suis isolates from porcine endocarditis and its biological significance
J. Med. Microbiol. 60, 1669 (2011); https://doi.org/10.1099/jmm.0.034686-0
/content/journal/jmm/10.1099/jmm.0.034686-0
/content/journal/jmm/10.1099/jmm.0.034686-0
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