1887

Abstract

species have emerged as opportunistic nosocomial pathogens in intensive care units. Epidemic spread and outbreaks of multidrug-resistant or carbapenem-resistant infections have been described worldwide. Species distribution, antimicrobial resistance and genotypes were investigated for species isolates collected from a single institution in Korea over 7 years. Two hundred and eighty-seven species isolates were collected from patients with bloodstream infections in one Korean hospital from 2003 to 2010. Most of them belonged to the complex (94.4 %). The most frequently isolated species was (44.2 %), followed by (formerly genomic species 13TU) (34.1 %). The proportion of increased significantly from 2008 to 2010 (40.4 to 50.0 %). From 2008, imipenem and meropenem resistance rates increased significantly compared with 2003–2007 (12.9 % and 20.5 %, respectively, to 41.4 % and 41.5 %, respectively). An increased carbapenem resistance rate between the two periods was identified more clearly amongst isolates. Polymyxin-resistant isolates emerged in 2008–2010, despite the availability of few isolates. The increase of carbapenem resistance in might be due to the substitution of main clones. Although ST92 and ST69 were the most prevalent clones amongst in 2003–2007 (47.8 % and 15.9 %, respectively), ST75 and ST138 had increased in 2008–2010 (39.7 % and 25.9 %, respectively). Although ST92 showed moderate resistance to carbapenems, most ST75 and ST138 isolates were resistant to carbapenems. All ST75 and ST138 isolates, but only one ST92 isolate, contained the gene. Increased carbapenem resistance in species and isolates might be due to the expansion of specific carbapenem-resistant clones.

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2012-01-01
2024-12-14
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