%0 Journal Article %A Mirza, Zahid Mehmood %A Kumar, Ashwani %A Kalia, Nitin Pal %A Zargar, Afzal %A Khan, Inshad Ali %T Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus %D 2011 %J Journal of Medical Microbiology, %V 60 %N 10 %P 1472-1478 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.033167-0 %I Microbiology Society, %X Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mupr-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2 % mupirocin. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.033167-0