1887

Abstract

Piperine, a --isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against strains including meticillin-resistant . The combination markedly reduced the MIC of mupirocin and also lowered the mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mup-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine with mupirocin in a dermal infection model of mice showed better efficacy when compared with the commercially available formulation of 2 % mupirocin.

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2011-10-01
2020-02-19
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