1887

Abstract

Seven epidemiologically unrelated cases of invasive type a (Hia) disease were identified in First Nations communities of Northwestern Ontario, Canada, in 2004–2008. In all cases, Hia was isolated from blood. The clinical presentation in most of the cases was moderately severe and all patients responded to antibiotic therapy. Laboratory analysis of Hia isolates from Northwestern Ontario indicated striking similarities in their phenotypic and genotypic characteristics. The findings are discussed in the context of current epidemiology of invasive Hia disease. Our data along with some published studies by others suggest an increased susceptibility to this infection among North American indigenous populations.

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2011-03-01
2024-03-28
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References

  1. Adam H. J., Richardson S. E., Jamieson F. B., Rawte P., Low D. E., Fisman D. N. 2010; Changing epidemiology of invasive Haemophilus influenzae in Ontario, Canada: evidence for herd effects and strain replacement due to Hib vaccination. Vaccine 28:4073–4078 [CrossRef]
    [Google Scholar]
  2. Adderson E. E., Byington C. L., Spencer L., Kimball A., Hindiyeh M., Carroll K., Mottice S., Korgenski E. K., Christenson J. C., Pavia A. T. 2001; Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b: emerging pathogen in the vaccine era?. Pediatrics 108:e18 [CrossRef]
    [Google Scholar]
  3. Bajanca P., Caniça M. the Multicenter Study Group 2004; Emergence of nonencapsulated and encapsulated non-b-type invasive Haemophilus influenzae isolates in Portugal (1989-2001). J Clin Microbiol 42:807–810 [CrossRef]
    [Google Scholar]
  4. Barbour M. L. 1996; Conjugate vaccines and the carriage of Haemophilus influenzae type b. Emerg Infect Dis 2:176–182 [CrossRef]
    [Google Scholar]
  5. Brown V. M., Madden S., Kelly L., Jamieson F. B., Tsang R. S. W., Ulanova M. 2009; Invasive Haemophilus influenzae disease caused by non-type b strains in Northwestern Ontario, Canada, 2002-2008. Clin Infect Dis 49:1240–1243 [CrossRef]
    [Google Scholar]
  6. Bruce M. G., Deeks S. L., Zulz T., Navarro C., Palacios C., Case C., Hemsley C., Hennessy T., Corriveau A. other authors 2008; Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000-2005. Emerg Infect Dis 14:48–55 [CrossRef]
    [Google Scholar]
  7. Degani N., Navarro C., Deeks S. L., Lovgren M. 2008; Invasive bacterial diseases in northern Canada. Emerg Infect Dis 14:34–40 [CrossRef]
    [Google Scholar]
  8. de Pádua R. A. F., de Lima Scodro R. B., Ghiraldi L. D., Siqueira V. L. D., Yamashita Y. K., Helbel C., Cardoso R. F. 2009; Haemophilus influenzae serotype a meningitis. Ann Clin Lab Sci 39:405–408
    [Google Scholar]
  9. Dworkin M. S., Park L., Borchardt S. M. 2007; The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons ≥ 65 years old. Clin Infect Dis 44:810–816 [CrossRef]
    [Google Scholar]
  10. Hammitt L. L., Block S., Hennessy T. W., Debyle C., Peters H., Parkinson A., Singleton R., Butler J. C. 2005; Outbreak of invasive Haemophilus influenzae serotype a disease. Pediatr Infect Dis J 24:453–456 [CrossRef]
    [Google Scholar]
  11. Hammitt L. L., Hennessy T. W., Romero-Steiner S., Butler J. C. 2006; Assessment of carriage of Haemophilus influenzae type a after a case of invasive disease. Clin Infect Dis 43:386–387 [CrossRef]
    [Google Scholar]
  12. Heath P. T., Booy R., Azzopardi H. J., Slack M. P., Fogarty J., Moloney A. C., Ramsay M. E., Moxon E. R. 2001; Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era. Pediatr Infect Dis J 20:300–305 [CrossRef]
    [Google Scholar]
  13. Jin Z., Romero-Steiner S., Carlone G. M., Robbins J. B., Schneerson R. 2007; Haemophilus influenzae type a infection and its prevention. Infect Immun 75:2650–2654 [CrossRef]
    [Google Scholar]
  14. Kapogiannis B. G., Satola S., Keyserling H. L., Farley M. M. 2005; Invasive infections with Haemophilus influenzae serotype a containing an IS 1016 - bexA partial deletion: possible association with virulence. Clin Infect Dis 41:e97–e103 [CrossRef]
    [Google Scholar]
  15. Kilian M. 2007; Haemophilus . In Manual of Clinical Microbiology, 9th edn. pp 636–648 Edited by Murray P. R., Baron E. J., Jorgensen J. H., Landry M. L., Pfaller M. A. Washington, DC: American Society for Microbiology;
    [Google Scholar]
  16. Kroll J. S., Moxon E. R., Loynds B. M. 1993; An ancestral mutation enhancing the fitness and increasing the virulence of Haemophilus influenzae type b. J Infect Dis 168:172–176 [CrossRef]
    [Google Scholar]
  17. Kroll J. S., Moxon E. R., Loynds B. M. 1994; Natural genetic transfer of a putative virulence-enhancing mutation to Haemophilus influenzae type a. J Infect Dis 169:676–679 [CrossRef]
    [Google Scholar]
  18. Ladhani S., Slack M. P., Heath P. T., von Gottberg A., Chandra M., Ramsay M. E. European Union Invasive Bacterial Infection Surveillance participants; 2010; Invasive Haemophilus influenzae disease, Europe, 1996–2006. Emerg Infect Dis 16:455–463 [CrossRef]
    [Google Scholar]
  19. Lau S. K., Woo P. C., Mok M. Y., Teng J. L., Tam V. K., Chan K. K., Yuen K. Y. 2004; Characterization of Haemophilus segnis , an important cause of bacteremia, by 16S rRNA gene sequencing. J Clin Microbiol 42:877–880 [CrossRef]
    [Google Scholar]
  20. Leaves N. I., Falla T. J., Crook D. W. M. 1995; The elucidation of novel capsular genotypes of Haemophilus influenzae type b with the polymerase chain reaction. J Med Microbiol 43:120–124 [CrossRef]
    [Google Scholar]
  21. Lima J. B. T., Ribeiro G. S., Cordeiro S. M., Gouveia E. L., Salgado K., Spratt B. G., Godoy D., Reis M. G., Ko A. I., Reis J. N. 2010; Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS 1016 - bexA deletion. J Infect Dis 202:1577–1584 [CrossRef]
    [Google Scholar]
  22. McConnell A., Tan B., Scheifele D., Halperin S., Vaudry W., Law B., Embree J. of The Canadian Immunization Monitoring Program. ACTive (IMPACT 2007; Invasive infections caused by Haemophilus influenzae serotypes in twelve Canadian IMPACT centers, 1996-2001. Pediatr Infect Dis J 26:1025–1031 [CrossRef]
    [Google Scholar]
  23. Millar E. V., O'Brien K. L., Watt J. P., Lingappa J., Pallipamu R., Rosenstein N., Hu D., Reid R., Santosham M. 2005; Epidemiology of invasive Haemophilus influenzae type A disease among Navajo and White Mountain Apache children, 1988-2003. Clin Infect Dis 40:823–830 [CrossRef]
    [Google Scholar]
  24. Morris S. K., Moss W. J., Halsey N. 2008; Haemophilus influenzae type b conjugate vaccine use and effectiveness. Lancet Infect Dis 8:435–443 [CrossRef]
    [Google Scholar]
  25. Murphy T. F. 2005; Haemophilus infections. In Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 6th edn. vol. 2 pp 2661–2669 Edited by Mandell G. L., Bennett J. E., Dolin R. Philadelphia: Churchill Livingstone;
    [Google Scholar]
  26. Peltola H. 1993; H. influenzae in the post-vaccination era. Lancet 341:864–865 [CrossRef]
    [Google Scholar]
  27. Pittman M. 1931; Variation and type specificity in the bacterial species Haemophilus influenzae . J Exp Med 53:471–492 [CrossRef]
    [Google Scholar]
  28. Public Health Agency of Canada 2006; Notifiable Diseases Online. Updated: January 13, 2006. Available at . Accessed 10 September 2010 http://dsol-smed.phac-aspc.gc.ca/dsol-smed/ndis/list_e.html
  29. Ribeiro G. S., Reis J. N., Cordeiro S. M., Lima J. B., Gouveia E. L., Petersen M., Salgado K., Silva H. R., Zanella R. C. other authors 2003; Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. J Infect Dis 187:109–116 [CrossRef]
    [Google Scholar]
  30. Rutherford G. W., Wilfert C. M. 1984; Invasive Haemophilus influenzae type a infections: a report of two cases and a review of the literature. Pediatr Infect Dis 3:575–577 [CrossRef]
    [Google Scholar]
  31. Sill M. L., Law D. K. S., Zhou J., Skinner S., Wylie J., Tsang R. S. W. 2007a; Population genetics and antibiotic susceptibility of invasive Haemophilus influenzae in Manitoba, Canada, from 2000 to 2006. FEMS Immunol Med Microbiol 51:270–276 [CrossRef]
    [Google Scholar]
  32. Sill M. L., Zhou J., Law D. K., Lorange M., Ringuette L., Bekal S., Tsang R. S. W. 2007b; Molecular characterization of four Haemophilus influenzae serotype a strains isolated from patients in Quebec, Canada. Can J Microbiol 53:1191–1194 [CrossRef]
    [Google Scholar]
  33. [Google Scholar]
  34. Tsang R. S. W. 2007; Capsule switching and capsule replacement in vaccine-preventable bacterial diseases. Lancet Infect Dis 7:569–570 [CrossRef]
    [Google Scholar]
  35. Tsang R. S. W., Mubareka S., Sill M. L., Wylie J., Skinner S., Law D. K. S. 2006; Invasive Haemophilus influenzae in Manitoba, Canada, in the postvaccination era. J Clin Microbiol 44:1530–1535 [CrossRef]
    [Google Scholar]
  36. Tsang R. S. W., Sill M. L., Skinner S. J., Law D. K., Zhou J., Wylie J. 2007; Characterization of invasive Haemophilus influenzae disease in Manitoba, Canada, 2000–2006: invasive disease due to non-type b strains. Clin Infect Dis 44:1611–1614 [CrossRef]
    [Google Scholar]
  37. Ulanova M., Tsang R. S. W. 2009; Invasive Haemophilus influenzae disease: changing epidemiology and host-parasite interactions in the 21st century. Infect Genet Evol 9:594–605 [CrossRef]
    [Google Scholar]
  38. Walker R., Cromarty H., Kelly L., St Pierre-Hansen N. 2009; Achieving cultural safety in Aboriginal health services: implementation of a crosscultural safety model in a hospital setting. Divers Health Care 6:11–22
    [Google Scholar]
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