1887

Abstract

A high carriage rate of multidrug-resistant (MDREC) was observed in elderly residents in long-term care facilities. A double-blinded, placebo-controlled trial was carried out to determine whether the probiotic product strain Nissle 1917 (Mutaflor) would compete with MDREC in the bowel and thereby reduce the prevalence of the multiresistant bacteria in faeces and urine. Sixty-nine patients excreting norfloxacin-resistant were randomized to probiotic or placebo groups and administered capsules twice daily. The daily dose of probiotic was 5×10–5×10 bacteria. Faecal and urine samples were cultured at baseline and during and after the treatment period. A reduction in baseline carriage was not influenced by probiotic administration. The probiotic strain was detected in faecal specimens collected during the treatment period of only two out of 12 probiotic group subjects that were tested. Genotyping of norfloxacin-resistant isolates showed that 32 strains were prevalent among the patients. Thus, Nissle 1917 does not have the capacity to compete effectively with MDREC in the bowel of elderly patients.

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2011-03-01
2019-10-18
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