@article{mbs:/content/journal/jmm/10.1099/jmm.0.025833-0, author = "Cascio, Antonio and Giordano, Salvatore and Dones, Piera and Venezia, Silvia and Iaria, Chiara and Ziino, Ottavio", title = "Haemophagocytic syndrome and rickettsial diseases", journal= "Journal of Medical Microbiology", year = "2011", volume = "60", number = "4", pages = "537-542", doi = "https://doi.org/10.1099/jmm.0.025833-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.025833-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "RMSF, Rocky Mountain spotted fever", keywords = "NK, natural killer", keywords = "ARNAS, Azienda di Rilievo Nazionale di Alta Specializzazione", keywords = "RR, reference range", keywords = "HME, human monocytic ehrlichiosis", keywords = "MSF, Mediterranean spotted fever", keywords = "HLH, haemophagocytic lymphohistiocytosis", abstract = "Haemophagocytic lymphohistiocytosis is a rare but potentially fatal disease resulting from dysregulated activation and proliferation of lymphocytes. We present a case of haemophagocytic syndrome occurring in a 5-year-old Italian boy as a complication of Mediterranean spotted fever. The characteristics of this case have been analysed and contextualized among those of another 15 cases of haemophagocytic syndrome associated with rickettsial diseases found through a systematic review of the international literature.", }