1887

Abstract

The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six of 46 active components found in TCMs were identified as putative QSIs based on molecular docking studies. Of these, three compounds inhibited biofilm formation by and at a concentration of 200 µM. A fourth compound (emodin) significantly inhibited biofilm formation at 20 µM and induced proteolysis of the quorum-sensing signal receptor TraR in at a concentration of 3–30 mM. Emodin also increased the activity of ampicillin against Therefore, emodin might be suitable for development into an antivirulence and antibacterial agent.

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2011-12-01
2019-08-17
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