1887

Abstract

We characterized 17 clinical isolates of producing 16S rRNA methylase ArmA. The isolates originated in Poland from 2002 to May 2010 and encompassed four I-PFGE clusters. All the isolates were resistant to amikacin, gentamicin and kanamycin (MIC range: 256–1024 mg l) and carried the gene on a large plasmid of approximately 90 or 130 kb in 15 and 2 isolates, respectively. The gene was found in a ~10 kb I restriction fragment of the large plasmid and was flanked by the same elements as in Tn. All the isolates carried the gene for a CTX-M-type extended-spectrum β-lactamase. Our results show that ArmA has disseminated horizontally among isolates in Poland on the ~90 kb plasmid of the pCTX-M3 family.

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2011-09-01
2019-10-17
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