1887

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Volume 60, Issue 3

Epidemiology of candidaemia in critically ill trauma patients: experiences of a level I trauma centre in North India Free

Abstract

There is a need to understand the epidemiology and risk factors associated with candidaemia in critically ill trauma patients. The rise in incidence of non- candidaemia and the emergence of antifungal resistance have made such a study necessary. A prospective laboratory-based surveillance study was performed over a period of 21 months (April 2008–December 2009) at a level I trauma centre in New Delhi, India. All blood culture samples positive for were processed for microbial identification by standard methods. Identification was carried out by conventional methods, using chromogenic medium (CHROMagar ) and by the automated Vitek 2 system. These isolates were characterized for their susceptibility to amphotericin B, fluconazole, flucytosine and voriconazole. Eighty-nine episodes of candidaemia occurred in 89 patients during the study period. The incidence was 0.71 episodes per 1000 patient days. A total of 136 isolates were obtained, with non- species accounting for over 80 %. , a rarely isolated pathogen, accounted for 25 (18.4 %) of the isolates, and 5.9 % of the isolates were resistant to fluconazole. None of the isolates showed resistance against amphotericin B, flucytosine or voriconazole. The present study revealed that non- species caused most of the cases of candidaemia in the trauma patients. The isolation of from a large number of cases highlights the ability of this rarely reported pathogen to cause bloodstream infections. The presence of azole resistance among many of the isolates is a matter of concern.

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Keyword(s): CLSI, Clinical and Laboratory Standards Institute , CVC, central venous catheter , ICU, intensive care unit , IDSA, Infectious Diseases Society of America and SDD, susceptible-dose dependent
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2011-03-01
2024-04-19
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Epidemiology of candidaemia in critically ill trauma patients: experiences of a level I trauma centre in North India
J. Med. Microbiol. 60, 342 (2011); https://doi.org/10.1099/jmm.0.023739-0
/content/journal/jmm/10.1099/jmm.0.023739-0
/content/journal/jmm/10.1099/jmm.0.023739-0
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