1887

Abstract

Vancomycin-resistant (VRE) infection is a rare event in paediatric patients and often occurs under immunosuppression or after surgical intervention. We report what we believe to be the first paediatric case of ventriculitis due to VRE (in a 2-month-old infant) to be successfully treated with combined intravenous (i.v.) and intraventricular chloramphenicol after failure of i.v. linezolid and intraventricular gentamicin.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.022921-0
2010-11-01
2019-11-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/59/11/1371.html?itemId=/content/journal/jmm/10.1099/jmm.0.022921-0&mimeType=html&fmt=ahah

References

  1. Anderson, K. F. & Ellis, F. G. ( 1951; ). Intrathecal chloramphenicol in staphylococcal meningitis resistant to penicillin and streptomycin. BMJ 2, 1067––1069.[CrossRef]
    [Google Scholar]
  2. Arnell, K., Enblad, P., Wester, T. & Sjölin, J. ( 2007; ). Treatment of cerebrospinal fluid shunt infections in children using systemic and intraventricular antibiotic therapy in combination with externalization of the ventricular catheter: efficacy in 34 consecutively treated infections. J Neurosurg 107, 213––219.
    [Google Scholar]
  3. Baysallar, M., Izci, Y., Kilic, A., Avci, I. Y., Senses, Z. & Doganci, L. ( 2006; ). A case of ventricular drainage infection with a rare pathogen in cerebrospinal fluid: vancomycin-resistant Enterococcus faecium. Microb Drug Resist 12, 59––62.[CrossRef]
    [Google Scholar]
  4. da Silva, P. S., Monteiro Neto, H. & Sejas, L. M. ( 2007; ). Successful treatment of vancomycin-resistant enterococcus ventriculitis in a child. Braz J Infect Dis 11, 297––299.[CrossRef]
    [Google Scholar]
  5. Friedman, C. A., Lovejoy, F. C. & Smith, A. L. ( 1979; ). Chloramphenicol disposition in infants and children. J Pediatr 95, 1071––1077.[CrossRef]
    [Google Scholar]
  6. Graham, P. L., Ampofo, K. & Saiman, L. ( 2002; ). Linezolid treatment of vancomycin-resistant Enterococcus faecium ventriculitis. Pediatr Infect Dis J 21, 798––800.[CrossRef]
    [Google Scholar]
  7. McLaurin, R. L. ( 1973; ). Infected cerebrospinal fluid shunts. Surg Neurol 1, 191––195.
    [Google Scholar]
  8. Mulhall, A., de Louvois, J. & Hurley, R. ( 1983; ). Chloramphenicol toxicity in neonates: its incidence and prevention. Br Med J (Clin Res Ed) 287, 1424––1427.[CrossRef]
    [Google Scholar]
  9. Nahata, M. C. ( 1989; ). Lack of predictability of chloramphenicol toxicity in pediatric patients. J Clin Pharm Ther 14, 297––303.[CrossRef]
    [Google Scholar]
  10. Pai, M. P., Rodvold, K. A., Schreckenberger, P. C., Gonzales, R. D., Petrolatti, J. M. & Quinn, J. P. ( 2002; ). Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium. Clin Infect Dis 35, 1269––1272.[CrossRef]
    [Google Scholar]
  11. Pérez Mato, S., Robinson, S. & Bégué, R. E. ( 1999; ). Vancomycin-resistant Enterococcus faecium meningitis successfully treated with chloramphenicol. Pediatr Infect Dis J 18, 483––484.[CrossRef]
    [Google Scholar]
  12. Salmon, J. H. ( 1978; ). Intraventricular chloramphenicol. Childs Brain 4, 114––119.
    [Google Scholar]
  13. Scapellato, P. G., Ormazabal, C., Scapellato, J. L. & Bottaro, E. G. ( 2005; ). Meningitis due to vancomycin-resistant Enterococcus faecium successfully treated with combined intravenous and intraventricular chloramphenicol. J Clin Microbiol 43, 3578––3579.[CrossRef]
    [Google Scholar]
  14. Webster, D. P., Griffiths, S. & Bowler, I. C. ( 2009; ). Failure of linezolid therapy for post-neurosurgical meningitis due to Enterococcus faecium. J Antimicrob Chemother 63, 622––623.[CrossRef]
    [Google Scholar]
  15. Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P. & Edmond, M. B. ( 2004; ). Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39, 309––317.[CrossRef]
    [Google Scholar]
  16. Zeana, C., Kubin, C. J., Della-Latta, P. & Hammer, S. M. ( 2001; ). Vancomycin-resistant Enterococcus faecium meningitis successfully managed with linezolid: case report and review of the literature. Clin Infect Dis 33, 477––482.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.022921-0
Loading
/content/journal/jmm/10.1099/jmm.0.022921-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error