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Volume 60, Issue 2

Integron types, gene cassettes, antimicrobial resistance genes and plasmids of isolates from outbreaks and sporadic cases in Taiwan Free

Abstract

This study analysed the presence, location and transferability of integrons and antibiotic resistance genes in 103 outbreak isolates and in 32 sporadic isolates from Taiwan. Multiple antimicrobial resistance was common in both outbreak (95 %) and sporadic (97 %) isolates. Class 1 integrons were present in 34 outbreak isolates (33 %) and in six sporadic isolates (19 %). This study is the first, to our knowledge, to identify an atypical -associated class 1 integron carrying the cassette array in . Class 2 integrons carrying the -- cassette array were predominant in outbreak isolates (90 %) but were not present in sporadic isolates. Other antimicrobial resistance genes not associated with integrons were found to encode resistance to ampicillin ( ), chloramphenicol (), sulfonamide () and tetracycline ( and ). The most common plasmid size was 130 kb (observed in 43 and 97 % of 1998 outbreak and sporadic isolates, respectively). In conclusion, the plasmid location of resistance genes and horizontal plasmid transfer promote the spread of multiple resistance genes in outbreak and sporadic isolates of .

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2011-02-01
2024-04-18
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Integron types, gene cassettes, antimicrobial resistance genes and plasmids of Shigella sonnei isolates from outbreaks and sporadic cases in Taiwan
J. Med. Microbiol. 60, 197 (2011); https://doi.org/10.1099/jmm.0.022517-0
/content/journal/jmm/10.1099/jmm.0.022517-0
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