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Journal of Medical Microbiology logo Journal of Medical Microbiology

Volume 60, Issue 10

Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009 No Access

Abstract

The genetic characteristics of mumps virus (MuV) strains isolated from sporadic mumps cases between 2007 and 2009 in three provinces of south-west China were investigated. MuV detection was carried out by nested RT-PCR on 117 cases. The small hydrophobic gene of 33 isolated strains was identified, and sequence analysis revealed that all the isolates belonged to the lineage genotype F with slight nucleotide variation. Furthermore, the virus haemagglutinin–neuraminidase and nucleoprotein antigens exhibited a high degree of nucleotide and amino acid similarity (>99 %) within all isolates, whilst the fusion protein appeared to have certain geographical differences. This study on molecular surveillance will help to monitor the circulation of MuV in China.

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© 2011 SGM
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2011-10-01
2025-05-17
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References

  1. Afzal M. A., Buchanan J., Heath A. B., Minor P. D. 1997; Clustering of mumps virus isolates by SH gene sequence only partially reflects geographical origin. Arch Virol 142:227–238 [View Article][PubMed]
     [Google Scholar]
  2. Al-Mazrou Y. Y., Khalil M. K., Tischer A., Al-Jeffri M. H., Al-Ghamdi Y. S., Bakhsh M. M., Mishkas A. A., Elgizouli S. A. 2005; Serosurvey of measles, mumps and rubella antibodies in Saudi children. Saudi Med J 26:1551–1554[PubMed]
     [Google Scholar]
  3. Bo F., Cui A. L., Guo X. B. 2009; [Analysis of epidemiological and pathogen characters of mumps in China from 2004 to 2006]. Zhongguo Yi Miao He Mian Yi 15:115–118 (in Chinese) [PubMed]
     [Google Scholar]
  4. Boga J. A., de Oña M., Fernández-Verdugo A., González D., Morilla A., Arias M., Barreiro L., Hidalgo F., Melón S. 2008; Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain. J Clin Virol 42:425–428 [View Article][PubMed]
     [Google Scholar]
  5. Chen M., Zhang T. G., Chen L. J., Wu J., Yang J., Zhang W. 2009; [Comparison of genotype characteristics between the circulating mumps virus strain in Beijing area and the vaccine strain]. Zhonghua Liu Xing Bing Xue Za Zhi 30:1184–1188 (in Chinese) [PubMed]
     [Google Scholar]
  6. Cheng W.-Y., Lee L., Rota P. A., Yang D. C. 2009; Molecular evolution of measles viruses circulated in Taiwan 1992-2008. Virol J 6:219 [View Article][PubMed]
     [Google Scholar]
  7. Chinese Center for Disease Control and Prevention 2007; National incidence and death cases of notifiable infectious diseases. http://211.167.248.16/n272442/n272530/n272757/22140.html
  8. Chinese Center for Disease Control and Prevention 2008; National incidence and death cases of notifiable infectious diseases. http://211.167.248.16/n272442/n272530/n272757/29344.html
  9. Chinese Center for Disease Control and Prevention 2009; National incidence and death cases of notifiable infectious diseases. http://211.167.248.16/n272442/n272530/n272757/35766.html
  10. Cui A., Myers R., Xu W., Jin L. 2009; Analysis of the genetic variability of the mumps SH gene in viruses circulating in the UK between 1996 and 2005. Infect Genet Evol 9:71–80 [View Article][PubMed]
     [Google Scholar]
  11. Hindiyeh M. Y., Aboudy Y., Wohoush M., Shulman L. M., Ram D., Levin T., Frank T., Riccardo F., Khalili M. et al. 2009; Characterization of large mumps outbreak among vaccinated Palestinian refugees. J Clin Microbiol 47:560–565 [View Article][PubMed]
     [Google Scholar]
  12. Isomura S., Miyazu M., Nagai H., Naruse H., Shibata M., Ichikawa T., Suzuki S., Yamanishi K., Takahashi M. 1982; Studies on live attenuated mumps vaccine. III. Long-term follow-up study on the efficacy of Biken vaccine. Biken J 25:63–69[PubMed]
     [Google Scholar]
  13. Ivancic J., Gulija T. K., Forcic D., Baricevic M., Jug R., Mesko-Prejac M., Mazuran R. 2005; Genetic characterization of L-Zagreb mumps vaccine strain. Virus Res 109:95–105 [View Article][PubMed]
     [Google Scholar]
  14. Jin L., Rima B., Brown D., Orvell C., Tecle T., Afzal M., Uchida K., Nakayama T., Song J. W. et al. 2005; Proposal for genetic characterisation of wild-type mumps strains: preliminary standardisation of the nomenclature. Arch Virol 150:1903–1909 [View Article][PubMed]
     [Google Scholar]
  15. Kim S. H., Song K. J., Shin Y. K., Kim J. H., Choi S. M., Park K. S., Baek L. J., Lee Y. J., Song J. W. 2000; Phylogenetic analysis of the small hydrophobic (SH) gene of mumps virus in Korea: identification of a new genotype. Microbiol Immunol 44:173–177[PubMed] [CrossRef]
     [Google Scholar]
  16. Kulkarni-Kale U., Ojha J., Manjari G. S., Deobagkar D. D., Mallya A. D., Dhere R. M., Kapre S. V. 2007; Mapping antigenic diversity and strain specificity of mumps virus: a bioinformatics approach. Virology 359:436–446 [View Article][PubMed]
     [Google Scholar]
  17. Kumar S., Tamura K., Nei M. 2004; mega3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5:150–163 [View Article][PubMed]
     [Google Scholar]
  18. Lászik Z. G., Kallajoki M., Hyypiä T., Rima B., Aho H. J., Nevalainen T. J. 1990; Mumps, enteroviruses, and human acute pancreatitis. Scand J Gastroenterol 25:906–910 [View Article][PubMed]
     [Google Scholar]
  19. Moriuchi H. 2001; [Mumps]. Nippon Rinsho 59:Suppl. 780–82 (in Japanese) [PubMed]
     [Google Scholar]
  20. Mühlemann K. 2004; The molecular epidemiology of mumps virus. Infect Genet Evol 4:215–219 [View Article][PubMed]
     [Google Scholar]
  21. Nikolić P., Apostolski A., Kaljalović R., Bojić I. 1978; [Acute myocarditis, pancreatitis and orchitis during mumps virus infection]. Vojnosanit Pregl 35:448–450 (in Serbian) [PubMed]
     [Google Scholar]
  22. Pebody R. G., Gay N. J., Hesketh L. M., Vyse A., Morgan-Capner P., Brown D. W., Litton P., Miller E. 2002; Immunogenicity of second dose measles-mumps-rubella (MMR) vaccine and implications for serosurveillance. Vaccine 20:1134–1140 [View Article][PubMed]
     [Google Scholar]
  23. Saijo M., Fujita K. 1997; [Central nervous system infection caused by mumps virus]. Nippon Rinsho 55:870–875 (in Japanese) [PubMed]
     [Google Scholar]
  24. Santos C. L., Ishida M. A., Foster P. G., Sallum M. A., Benega M. A., Borges D. B., Corrêa K. O., Constantino C. R., Afzal M. A., Paiva T. M. 2008; Detection of a new mumps virus genotype during parotitis epidemic of 2006–2007 in the state of São Paulo, Brazil. J Med Virol 80:323–329 [View Article][PubMed]
     [Google Scholar]
  25. Santos-López G., Scior T., Borraz-Argüello M. T., Vallejo-Ruiz V., Herrera-Camacho I., Tapia-Ramírez J., Reyes-Leyva J. 2009; Structure–function analysis of two variants of mumps virus hemagglutinin–neuraminidase protein. Braz J Infect Dis 13:24–34 [View Article][PubMed]
     [Google Scholar]
  26. Saraswathy T. S., Zahrin H. N., Norhashmimi H., Az-Ulhusna A., Zainah S., Rohani J. 2009; Impact of a measles elimination strategy on measles incidence in Malaysia. Southeast Asian J Trop Med Public Health 40:742–747[PubMed]
     [Google Scholar]
  27. WHO 2001; Mumps virus vaccines. Wkly Epidemiol Rec 76:346–355
     [Google Scholar]
  28. Wood C. B., Bradbrook R. A., Blumgart L. H. 1974; Chronic pancreatitis in childhood associated with mumps virus infection. Br J Clin Pract 28:67–69[PubMed]
     [Google Scholar]
/content/journal/jmm/10.1099/jmm.0.021907-0
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Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009
J. Med. Microbiol. 60, 1496 (2011); https://doi.org/10.1099/jmm.0.021907-0
/content/journal/jmm/10.1099/jmm.0.021907-0
/content/journal/jmm/10.1099/jmm.0.021907-0
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