1887

Abstract

Primary laryngeal aspergillosis is extremely rare, especially in an immunocompetent host. It is commonly found as part of a systemic infection involving the respiratory system in immunocompromised people. Two cases of laryngeal aspergillosis with no systemic extension and no generalized immune deficiency are presented here. We report what is to the best of our knowledge only the second case of infection in a vocal cord cyst. species were identified in tissue sections and confirmed by PCR studies. We present a literature review of laryngeal aspergillosis cases and discuss predisposing factors, clinical presentation, histopathology, PCR, diagnosis and treatment of laryngitis. The known aetiological causes of the disease are increasing and include iatrogenic factors, vocal abuse, vocal-fold cysts and occupational factors, and immunocompetent patients are susceptible to these predisposing factors.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.021634-0
2010-10-01
2019-11-18
Loading full text...

Full text loading...

/deliver/fulltext/jmm/59/10/1250.html?itemId=/content/journal/jmm/10.1099/jmm.0.021634-0&mimeType=html&fmt=ahah

References

  1. Agarwal, P., Yadav, R. P. & Upadhyay, S. N. ( 2001; ). A new method of detection and differentiation of pathogenic from non-pathogenic Aspergillus species. J Med Microbiol 50, 653–654.
    [Google Scholar]
  2. Athanassiadou, F., Kourti, M., Papageorgiou, T. & Danielidis, J. ( 2005; ). Invasive aspergillosis of the larynx in a child with acute lymphoblastic leukemia. Pediatr Infect Dis J 24, 190–191.
    [Google Scholar]
  3. Benson-Mitchell, R., Tolley, N., Croft, C. B. & Gallimore, A. ( 1994; ). Aspergillosis of the larynx. J Laryngol Otol 108, 883–885.
    [Google Scholar]
  4. Beust, L., Godey, B., Le Gall, F., Grollier, R. & Le Clech, G. ( 1998; ). Primary aspergillosis of the larynx and squamous cell carcinoma. Ann Otol Rhinol Laryngol 107, 851–854.[CrossRef]
    [Google Scholar]
  5. Dean, C. M., Hawkshaw, M. & Sataloff, R. T. ( 2001; ). Laryngeal aspergillosis. Ear Nose Throat J 80, 300.
    [Google Scholar]
  6. Fairfax, A. J., David, V. & Douce, G. ( 1999; ). Laryngeal aspergillosis following high dose inhaled fluticasone therapy for asthma. Thorax 54, 860–861.[CrossRef]
    [Google Scholar]
  7. Ferlito, A. ( 1974; ). Clinical records. Primary aspergillosis of the larynx. J Laryngol Otol 88, 1257–1263.[CrossRef]
    [Google Scholar]
  8. Kheir, S. M., Flint, A. & Moss, J. A. ( 1983; ). Primary aspergillosis of the larynx simulating carcinoma. Hum Pathol 14, 184–186.[CrossRef]
    [Google Scholar]
  9. Klein, A. M., Tiu, C. & Lafreniere, D. ( 2005; ). Malignant mimickers: chronic bacterial and fungal infections of the larynx. J Voice 19, 151–157.[CrossRef]
    [Google Scholar]
  10. McAlester, G., O'Gara, F. & Morrissey, J. P. ( 2008; ). Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans. J Med Microbiol 57, 563–569.[CrossRef]
    [Google Scholar]
  11. Mehanna, H. M., Kuo, T., Chaplin, J., Taylor, G. & Morton, R. P. ( 2004; ). Fungal laryngitis in immunocompetent patients. J Laryngol Otol 118, 379–381.
    [Google Scholar]
  12. Morelli, S., Sgreccia, A., Bernardo, M. L., Della Rocca, C., Gallo, A. & Valesini, G. ( 2000; ). Primary aspergillosis of the larynx in a patient with Felty's syndrome. Clin Exp Rheumatol 18, 523–524.
    [Google Scholar]
  13. Nagasawa, M., Itoh, S., Tomizawa, D., Kajiwara, M., Sugimoto, T. & Kumagai, J. ( 2002; ). Invasive subglottal aspergillosis in a patient with severe aplastic anemia: a case report. J Infect 44, 198–201.[CrossRef]
    [Google Scholar]
  14. Nakahira, M., Matsumoto, S., Mukushita, N. & Nakatani, H. ( 2002; ). Primary aspergillosis of the larynx associated with CD4+ T lymphocytopenia. J Laryngol Otol 116, 304–306.
    [Google Scholar]
  15. Nong, D., Nong, H., Li, J. & Huang, G. ( 1997; ). Aspergillosis of the larynx: a report of 8 cases. Chin Med J (Engl) 110, 734–736.
    [Google Scholar]
  16. Ogawa, Y., Nishiyama, N., Hagiwara, A., Ami, T., Fujita, H., Yoshida, T. & Suzuki, M. ( 2002; ). A case of laryngeal aspergillosis following radiation therapy. Auris Nasus Larynx 29, 73–76.[CrossRef]
    [Google Scholar]
  17. Rao, P. B. ( 1969; ). Aspergillosis of larynx. J Laryngol Otol 83, 377–379.[CrossRef]
    [Google Scholar]
  18. Sambatakou, H., Dupont, B., Lode, H. & Denning, D. W. ( 2006; ). Voriconazole treatment for subacute invasive and chronic pulmonary aspergillosis. Am J Med 119, e17–e24.
    [Google Scholar]
  19. Sriskandabalan, P. & Roy, R. B. ( 1996; ). Aspergillus infection of the epiglottis in a HIV positive patient. Genitourin Med 72, 431–432.
    [Google Scholar]
  20. Wittkopf, J., Connelly, S., Hoffman, H., Smith, R. & Robinson, R. ( 2006; ). Infection of true vocal fold cyst with Aspergillus. Otolaryngol Head Neck Surg 135, 660–661.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.021634-0
Loading
/content/journal/jmm/10.1099/jmm.0.021634-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error