@article{mbs:/content/journal/jmm/10.1099/jmm.0.020727-0, author = "Park, Joo-Hee and Shim, Tae-Sun and Lee, Seung-Ae and Lee, Hyungki and Lee, In-Kyung and Kim, Kijeong and Kook, Yoon-Hoh and Kim, Bum-Joon", title = "Molecular characterization of Mycobacterium intracellulare-related strains based on the sequence analysis of hsp65, internal transcribed spacer and 16S rRNA genes", journal= "Journal of Medical Microbiology", year = "2010", volume = "59", number = "9", pages = "1037-1043", doi = "https://doi.org/10.1099/jmm.0.020727-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.020727-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "MAC, Mycobacterium avium complex", keywords = " ITS1, internal transcribed spacer 1", keywords = "NTM, non-tuberculous mycobacteria", keywords = "PRA, PCR restriction analysis", keywords = "SNP, single nucleotide polymorphism", abstract = "We investigated the molecular epidemiological features of 94 Mycobacterium intracellulare-related strains, isolated from Korean patients, using sequence analysis targeting 3 independent chronometer molecules, hsp65, the internal transcribed spacer 1 region and the 16S rRNA gene. By collective consideration of these three gene-based approaches, the 94 strains were divided into 5 groups (INT1, INT2, INT3, INT4 and INT5). The frequencies of genotype INT1, 2, 3, 4 and 5 in the 94 isolates were 57.4 % (54), 27.7 % (26), 6.4 % (6), 5.3 % (5) and 3.2 % (3), respectively. When correlations between genotypes and clinical parameters (age, sex, radiological type and the presence of a cavity) were analysed in 78 patients with non-tuberculous mycobacteria pulmonary diseases, no relationships were observed with respect to age, sex and radiological type, but genotype and the presence of a cavity tended to be related (P=0.051).", }