Dermal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with in mice Free

Abstract

A single subcutaneous (s.c.) infection with 1×10 c.f.u. GAS472, a group A streptococcus (GAS) serotype M1 strain isolated from the blood of a patient suffering from streptococcal toxic shock syndrome, led to severe damage of striated muscle layers in the feet of mast cell (MC)-deficient WBB6F- () mice 72 h after infection. In contrast, no damage was recognized in striated muscle layers in the feet of the control WBB6F- (+/+) mice 72 h after infection. In addition, adoptively transferred MCs reduced progressive tissue necrosis of the feet of mice after infection. However, there was no significant difference in the mortality rates between the and +/+ mice, or between the human CD46-expressing transgenic (Tg) mouse bone marrow-derived cultured MC-reconstituted and non-Tg mouse bone marrow-derived cultured MC-reconstituted mice after infection. Consequently, although MCs can help to reduce the severity of necrosis of the feet caused by s.c. infection with GAS472, such reduction of tissue necrosis scarcely improves the mortality rates of these mice. Moreover, human CD46 does not play a crucial role in the MC-mediated innate immune defence against GAS infection.

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2011-01-01
2024-03-29
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References

  1. Bisno A. L., Stevens D. L. 1996; Streptococcal infections of skin and soft tissues. N Engl J Med 334:240–245 [CrossRef]
    [Google Scholar]
  2. Chatterjea D., Burns-Guydish S. M., Sciuto T. E., Dvorak A., Contag C. H., Galli S. J. 2005; Adoptive transfer of mast cells does not enhance the impaired survival of KitW/KitW-v mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium . Immunol Lett 99:122–129 [CrossRef]
    [Google Scholar]
  3. Di Nardo A., Yamasaki K., Dorschner R. A., Lai Y., Gallo R. L. 2008; Mast cell cathelicidin antimicrobial peptide prevents invasive group A streptococcus infection of the skin. J Immunol 180:7565–7573 [CrossRef]
    [Google Scholar]
  4. Ebmeyer J., Furukawa M., Pak K., Ebmeyer U., Sudhoff H., Broide D., Ryan A. F., Wasserman S. 2005; Role of mast cells in otitis media. J Allergy Clin Immunol 116:1129–1135 [CrossRef]
    [Google Scholar]
  5. Eguchi M., Sekiya Y., Suzuki M., Yamamoto T., Matsui H. 2007; An oral Salmonella vaccine promotes the down-regulation of cell surface Toll-like receptor 4 (TLR4) and TLR2 expression in mice. FEMS Immunol Med Microbiol 50:300–308 [CrossRef]
    [Google Scholar]
  6. Filbin M. R., Ring D. C., Wessels M. R., Avery L. L., Kradin R. L. 2009; Case records of the Massachusetts General Hospital. Case 2-2009; A 25-year-old man with pain and swelling of the right hand and hypotension. N Engl J Med 360:281–290 [CrossRef]
    [Google Scholar]
  7. Furuta T., Kikuchi T., Iwakura Y., Watanabe N. 2006; Protective roles of mast cells and mast cell-derived TNF in murine malaria. J Immunol 177:3294–3302 [CrossRef]
    [Google Scholar]
  8. Fustes-Morales A., Gutierrez-Castrellon P., Duran-Mckinster C., Orozco-Covarrubias L., Tamayo-Sanchez L., Ruiz-Maldonado R. 2002; Necrotizing fasciitis: report of 39 pediatric cases. Arch Dermatol 138:893–899
    [Google Scholar]
  9. Galli S. J., Nakae S., Tsai M. 2005; Mast cells in the development of adaptive immune responses. Nat Immunol 6:135–142 [CrossRef]
    [Google Scholar]
  10. Gekara N. O., Weiss S. 2008; Mast cells initiate early anti- Listeria host defences. Cell Microbiol 10:225–236
    [Google Scholar]
  11. Kitamura Y., Oboki K., Ito A. 2007; Development of mast cells. Proc Jpn Acad Ser B 83:164–174 [CrossRef]
    [Google Scholar]
  12. Kodama C., Eguchi M., Sekiya Y., Yamamoto T., Kikuchi Y., Matsui H. 2005; Evaluation of the Lon-deficient Salmonella strain as an oral vaccine candidate. Microbiol Immunol 49:1035–1045 [CrossRef]
    [Google Scholar]
  13. Leitch H. A., Palepu A., Fernandes C. M. 2000; Necrotizing fasciitis secondary to group A streptococcus. Morbidity and mortality still high. Can Fam Physician 46:1460–1466
    [Google Scholar]
  14. Leslie M. 2007; Mast cells show their might. Science 317:614–616 [CrossRef]
    [Google Scholar]
  15. Marshall J. S. 2004; Mast-cell responses to pathogens. Nat Rev Immunol 4:787–799 [CrossRef]
    [Google Scholar]
  16. Matsui H., Sekiya Y., Nakamura M., Murayama S. Y., Yoshida H., Takahashi T., Imanishi K., Tsuchimoto K., Uchiyama T. other authors 2009; CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection. Infect Immun 77:4806–4814 [CrossRef]
    [Google Scholar]
  17. Maurer M., Metz M. 2005; The status quo and quo vadis of mast cells. Exp Dermatol 14:923–929 [CrossRef]
    [Google Scholar]
  18. Maurer M., Lopez Kostka S., Siebenhaar F., Moelle K., Metz M., Knop J., von Stebut E. 2006; Skin mast cells control T cell-dependent host defense in Leishmania major infections. FASEB J 20:2460–2467 [CrossRef]
    [Google Scholar]
  19. Metz M., Siebenhaar F., Maurer M. 2008; Mast cell functions in the innate skin immune system. Immunobiology 213:251–260 [CrossRef]
    [Google Scholar]
  20. Miyoshi-Akiyama T., Zhao J., Kikuchi K., Kato H., Suzuki R., Endoh M., Uchiyama T. 2003; Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci. J Infect Dis 187:1876–1887 [CrossRef]
    [Google Scholar]
  21. Okada N., Liszewski M. K., Atkinson J. P., Caparon M. 1995; Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A 92:2489–2493 [CrossRef]
    [Google Scholar]
  22. Rezcallah M. S., Hodges K., Gill D. B., Atkinson J. P., Wang B., Cleary P. P. 2005; Engagement of CD46 and alpha5beta1 integrin by group A streptococci is required for efficient invasion of epithelial cells. Cell Microbiol 7:645–653 [CrossRef]
    [Google Scholar]
  23. Siebenhaar F., Syska W., Weller K., Magerl M., Zuberbier T., Metz M., Maurer M. 2007; Control of Pseudomonas aeruginosa skin infections in mice is mast cell-dependent. Am J Pathol 170:1910–1916 [CrossRef]
    [Google Scholar]
  24. Stefanini M., De Martino C., Zamboni L. 1967; Fixation of ejaculated spermatozoa for electron microscopy. Nature 216:173–174 [CrossRef]
    [Google Scholar]
  25. Steinstraesser L., Koehler T., Jacobsen F., Daigeler A., Goertz O., Langer S., Kesting M., Steinau H., Eriksson E., Hirsch T. 2008; Host defense peptides in wound healing. Mol Med 14:528–537
    [Google Scholar]
  26. Thakurdas S. M., Melicoff E., Sansores-Garcia L., Moreira D. C., Petrova Y., Stevens R. L., Adachi R. 2007; The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem 282:20809–20815 [CrossRef]
    [Google Scholar]
  27. Velin D., Bachmann D., Bouzourene H., Michetti P. 2005; Mast cells are critical mediators of vaccine-induced Helicobacter clearance in the mouse model. Gastroenterology 129:142–155 [CrossRef]
    [Google Scholar]
  28. Wei O. L., Hilliard A., Kalman D., Sherman M. 2005; Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium . Infect Immun 73:1978–1985 [CrossRef]
    [Google Scholar]
  29. Xu X., Zhang D., Lyubynska N., Wolters P. J., Killeen N. P., Baluk P., McDonald D. M., Hawgood S., Caughey G. H. 2006; Mast cells protect mice from Mycoplasma pneumonia. Am J Respir Crit Care Med 173:219–225 [CrossRef]
    [Google Scholar]
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