RT Journal Article SR Electronic(1) A1 Shen, Qian A1 Zhou, Hua A1 Li, Heng A1 Zhou, JianyingYR 2011 T1 Linezolid combined with trimethoprim–sulfamethoxazole therapy for the treatment of disseminated nocardiosis JF Journal of Medical Microbiology, VO 60 IS 7 SP 1043 OP 1045 DO https://doi.org/10.1099/jmm.0.018549-0 PB Microbiology Society, SN 1473-5644, AB We describe a case of disseminated nocardiosis in a 45-year-old male with a history of chronic glomerular nephritis and allograft renal transplantation both treated with immunosuppressive drugs. Clinical symptoms included fever, chest distress, breathlessness, subcutaneous nodules and pustules. Pulmonary computed tomography scans revealed areas of consolidation in both lung fields, pleural effusion and massive pericardial effusion. Bacterial culture of the pus in the subcutaneous abscesses and pericardial effusion showed growth of Nocardia asteroides sensitive to linezolid and trimethoprim–sulfamethoxazole (TMP-SMZ) for both. Treatment with linezolid combined with TMP-SMZ resulted in a clear clinical improvement and bacterial clearance., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.018549-0