%0 Journal Article %A Ye, Ying %A Xu, Xi-Hai %A Li, Jia-Bin %T Emergence of CTX-M-3, TEM-1 and a new plasmid-mediated MOX-4 AmpC in a multiresistant Aeromonas caviae isolate from a patient with pneumonia %D 2010 %J Journal of Medical Microbiology, %V 59 %N 7 %P 843-847 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.016337-0 %K ESBL, extended spectrum β-lactamase %I Microbiology Society, %X Aeromonas species rarely cause pulmonary infection. We report, for what is believed to be the first time, a case of severe pneumonia in a cancer patient caused by Aeromonas caviae. Detailed microbiological investigation revealed that this isolate carried three β-lactamase-encoding genes (encoding MOX-4, CTX-M-3 and TEM-1) conferring resistance to all β-lactams but imipenem. The β-lactamase with a pI of 9.0 was transferred by conjugation and associated with a 7.3 kb plasmid, as demonstrated by Southern blot hybridization. Analysis of the nucleotide and amino acid sequences showed a new ampC gene that was closely related to those encoding the MOX-1, MOX-2 and MOX-3 β-lactamases. This new plasmid-mediated AmpC β-lactamase from China was named MOX-4. This is believed to be the first report of MOX-4, CTX-M-3 and TEM-1 β-lactamases in a multiresistant A. caviae. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.016337-0