1887

Abstract

species rarely cause pulmonary infection. We report, for what is believed to be the first time, a case of severe pneumonia in a cancer patient caused by . Detailed microbiological investigation revealed that this isolate carried three -lactamase-encoding genes (encoding MOX-4, CTX-M-3 and TEM-1) conferring resistance to all -lactams but imipenem. The -lactamase with a pI of 9.0 was transferred by conjugation and associated with a 7.3 kb plasmid, as demonstrated by Southern blot hybridization. Analysis of the nucleotide and amino acid sequences showed a new gene that was closely related to those encoding the MOX-1, MOX-2 and MOX-3 -lactamases. This new plasmid-mediated AmpC -lactamase from China was named MOX-4. This is believed to be the first report of MOX-4, CTX-M-3 and TEM-1 -lactamases in a multiresistant

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2010-07-01
2019-10-15
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