1887

Abstract

Daptomycin is a novel lipopeptide with activity against Gram-positive organismsincluding enterococci. It is licensed for the treatment of bacteraemia and right-sided endocarditis, but not endocarditisdue to spp. We report a case of enterococcal prostheticvalve endocarditis with an aortic root abscess in an elderly patient who wasnot fit for surgery. The patient's endocarditis relapsed 9 weeks aftera 6 week course of daptomycin.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.016253-0
2010-04-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/59/4/482.html?itemId=/content/journal/jmm/10.1099/jmm.0.016253-0&mimeType=html&fmt=ahah

References

  1. Arias C. A., Torres H. A., Singh K. V., Panesso D., Moore J., Wanger A., Murray B. E. 2007; Failureof daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulationsand evidence of in vivo loss of the vanA gene cluster. Clin Infect Dis 45:1343–1346 [CrossRef]
    [Google Scholar]
  2. BNF 2008 British National Formulary , 55th edn. London: BMJ Publishing & RPS Publishing;
    [Google Scholar]
  3. Cunha B. A., Mickail N., Eisenstein L. 2007; E. faecalis vancomycin-sensitive enterococcal bacteremiaunresponsive to a vancomycin tolerant strain successfully treated with high-dosedaptomycin. Heart Lung 36:456–461 [CrossRef]
    [Google Scholar]
  4. Durack D. T., Lukes A. S., Bright D. K. Duke EndocarditisService 1994; New criteria for diagnosis of infectiveendocarditis: utilization of specific echocardiographic findings. Am J Med 96:200–209 [CrossRef]
    [Google Scholar]
  5. Elliott T. S. J., Foweraker J, Gould F. K., Perry J. D., Sandoe J. A. T. 2004; Guidelines for the antibiotictreatment of endocarditis in adults: report of the Working Party of the BritishSociety for Antimicrobial Chemotherapy. J Antimicrob Chemother 54:971–981 [CrossRef]
    [Google Scholar]
  6. Enoch D. A., Bygott J. M., Daly M. L., Karas J. A. 2007; Daptomycin. J Infect 55:205–213 [CrossRef]
    [Google Scholar]
  7. Fraher M. H., Corcoran G. D., Creagh S., Feeney E. 2007; Daptomycin-resistant Enteroccoccus faecium in a patient with no prior exposure to daptomycin. J HospInfect 65:376–378
    [Google Scholar]
  8. Kanafani Z. A., Federspiel J. J., Fowler V. G. Jr 2007; Infective endocarditis caused by daptomycin-resistantEnterococcus faecalis: a case report. Scand J Infect Dis 39:75–77 [CrossRef]
    [Google Scholar]
  9. Lesho E. P., Wortmann G. W., Craft D., Moran K. A. 2006; De novo daptomycin nonsusceptibility in aclinical isolate. J Clin Microbiol 44:673 [CrossRef]
    [Google Scholar]
  10. Levine D. P., Lamp K. C. 2007a Daptomycin experience for enterococcal endocarditis from a registry.In Abstracts of the 9th International Symposium on Modern Concepts inEndocarditis and Cardiovascular Infections p– 425 Heidelberg: InternationalSociety for Cardiovascular Infectious Diseases;
    [Google Scholar]
  11. Levine D. P., Lamp K. C. 2007b; Daptomycin in the treatment of patients with infective endocarditis: experience from a registry. Am J Med 120:S28–S33
    [Google Scholar]
  12. Lewis J. S. II, Owens A., Cadena J., Sabol K., Patterson J. E., Jorgensen J. H. 2005; Emergence ofdaptomycin resistance in Enterococcus faecium during daptomycin therapy. Antimicrob Agents Chemother 49:1664–1665 [CrossRef]
    [Google Scholar]
  13. Long J. K., Choueiri T. K., Hall G. S., Avery R. K., Sekeres M. A. 2005; Daptomycin-resistant Enterococcusfaecium in a patient with acute myeloid leukemia. Mayo ClinProc 80:1215–1216
    [Google Scholar]
  14. Mohan S. S., McDermott B. P., Cunha B. A. 2005; Methicillin-resistant Staphylococcus aureus prostheticaortic valve endocarditis with paravalvular abscess treated with daptomycin. Heart Lung 34:69–71 [CrossRef]
    [Google Scholar]
  15. Mohr J. F., Friedrich L. V., Yankelev S., Lamp K. C. 2009; Daptomycin for the treatment of enterococcalbacteraemia: results from the Cubicin Outcomes Registry and Experience (CORE. Int J Antimicrob Agents 33:543–548 [CrossRef]
    [Google Scholar]
  16. Munoz-Price L. S., Lolans K., Quinn J. P. 2005; Emergence of resistance to daptomycin during treatment ofvancomycin-resistant Enterococcus faecalis infection. Clin Infect Dis 41:565–566 [CrossRef]
    [Google Scholar]
  17. Schwartz B. S., Ngo P. D., Guglielmo B. J. 2008; Daptomycin treatment failure for vancomycin-resistant Enterococcus faecium infective endocarditis: impact of protein binding?. Ann Pharmacother 42:289–290 [CrossRef]
    [Google Scholar]
  18. Segreti J. A., Crank C. W., Finney M. S. 2006; Daptomycin for the treatment of gram-positive bacteremiaand infective endocarditis: a retrospective case series of 31 patients. Pharmacotherapy 26:347–352 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.016253-0
Loading
/content/journal/jmm/10.1099/jmm.0.016253-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error