1887

Abstract

Macrolide antibiotics are frequently administered to treat mycoplasmal pneumonia. However, macrolide-resistant has recently been isolated from clinical specimens in Japan. Clarithromycin (CAM) is a 14-membered-ring macrolide that has host immunomodulatory activity. Here, we established a gnotobiotic mouse model that was monoassociated with macrolide-resistant , and pathologically and microbiologically analysed the effects of antibiotics against mycoplasmal pneumonia. We also examined the immunomodulatory activities of macrolide antibiotics in human lung carcinoma A549 cells and in a specific-pathogen-free (SPF) mouse model of pneumonia induced by antigen . CAM anti-mycoplasma antibiotics decreased the number of macrolide-sensitive and -resistant in the lungs of gnotobiotic mice. Thus, in SPF mice, CAM modulated pulmonary inflammation induced by antigens.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.014191-0
2010-06-01
2019-11-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/59/6/693.html?itemId=/content/journal/jmm/10.1099/jmm.0.014191-0&mimeType=html&fmt=ahah

References

  1. Amsden, G. W. ( 2005; ). Anti-inflammatory effects of macrolides – an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother 55, 10–21.
    [Google Scholar]
  2. Anderson, R. ( 1989; ). Erythromycin and roxithromycin potentiate human neutrophil locomotion in vitro by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis 159, 966–973.[CrossRef]
    [Google Scholar]
  3. Butterton, J. R., Ryan, E. T., Shahin, R. A. & Calderwood, S. B. ( 1996; ). Development of a germfree mouse model of Vibrio cholerae infection. Infect Immun 64, 4373–4377.
    [Google Scholar]
  4. Carlone, N. A., Cufini, A. M., Tullio, V. & Sassella, D. ( 1989; ). Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 2. Chemotaxis and phagocytosis of 3H-Staphylococcus aureus by human macrophages. Microbios 58, 17–25.
    [Google Scholar]
  5. Chmura, K., Lutz, R. D., Chiba, H., Numata, M. S., Choi, H. J., Fantuzzi, G., Voelker, D. R. & Chan, E. D. ( 2003; ). Mycoplasma pneumoniae antigens stimulate interleukin-8. Chest 123, 425S [CrossRef]
    [Google Scholar]
  6. Cuffini, A. M., Carlone, N. A., Tullio, V. & Borsotto, M. ( 1989; ). Comparative effects of roxithromycin and erythromycin on cellular immune functions in vitro. 3. Killing of intracellular Staphylococcus aureus by human macrophages. Microbios 58, 27–33.
    [Google Scholar]
  7. Fernald, G. W., Clyde, W. A., Jr & Bienenstock, J. ( 1972; ). Immunoglobulin-containing cells in lungs of hamsters infected with Mycoplasma pneumoniae. J Immunol 108, 1400–1408.
    [Google Scholar]
  8. Ginestal, R. C., Plaza, J. F., Callejo, J. M., Rodríguez-Espinosa, N., Fernández-Ruiz, L. C. & Masjuán, J. ( 2004; ). Bilateral optic neuritis and Guillain-Barré syndrome following an acute Mycoplasma pneumoniae infection. J Neurol 251, 767–768.
    [Google Scholar]
  9. Gladue, R. P., Bright, G. M., Isaacson, R. E. & Newborg, M. F. ( 1989; ). In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 33, 277–282.[CrossRef]
    [Google Scholar]
  10. Hakkarainen, K., Turunen, H., Miettinen, A., Karppelin, M., Kaitila, K. & Jansson, E. ( 1992; ). Mycoplasmas and arthritis. Ann Rheum Dis 51, 1170–1172.[CrossRef]
    [Google Scholar]
  11. Hayakawa, M., Taguchi, H., Kamiya, S., Fujioka, Y., Watanabe, H., Kawai, S. & Kobayashi, H. ( 2002; ). Animal model of Mycoplasma pneumoniae infection using germfree mice. Clin Diagn Lab Immunol 9, 669–676.
    [Google Scholar]
  12. Ianaro, A., Ialenti, A., Maffia, P., Sautebin, L., Rombolà, L., Carnuccio, R., Iuvone, T., D'Acquisto, F. & Di Rosa, M. ( 2000; ). Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 292, 156–163.
    [Google Scholar]
  13. Johnson, J. D., Hand, W. L., Francis, J. B., King-Thompson, N. & Corwin, R. W. ( 1980; ). Antibiotic uptake by alveolar macrophages. J Lab Clin Med 95, 429–439.
    [Google Scholar]
  14. Kamiya, S., Taguchi, H., Yamaguchi, H., Osaki, T., Takahashi, M. & Nakamura, S. ( 1997; ). Bacterioprophylaxis using Clostridium butyricum for lethal caecitis by Clostridium difficile in gnotobiotic mice. Rev Med Microbiol 8, S57–S59.[CrossRef]
    [Google Scholar]
  15. Kawasaki, S., Takizawa, H., Ohtoshi, T., Takeuchi, N., Kohyama, T., Nakamura, H., Kasama, T., Kobayashi, K., Nakahara, K. & other authors ( 1998; ). Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro. Antimicrob Agents Chemother 42, 1499–1502.
    [Google Scholar]
  16. Kikuchi, T., Hagiwara, K., Honda, Y., Gomi, K., Kobayashi, T., Takahashi, H., Tokue, Y., Watanabe, A. & Nukiwa, T. ( 2002; ). Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors. J Antimicrob Chemother 49, 745–755.[CrossRef]
    [Google Scholar]
  17. Kohyama, T., Takizawa, H., Kawasaki, S., Akiyama, N., Sato, M. & Ito, K. ( 1999; ). Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. Antimicrob Agents Chemother 43, 907–911.
    [Google Scholar]
  18. Kudoh, S., Uetake, T., Hagiwara, K., Hirayama, M., Hus, L. H., Kimura, H. & Sugiyama, Y. ( 1987; ). Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis. Nihon Kyobu Shikkan Gakkai Zasshi 25, 632–642.
    [Google Scholar]
  19. Kudoh, S., Azuma, A., Yamamoto, M., Izumi, T. & Ando, M. ( 1998; ). Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med 157, 1829–1832.[CrossRef]
    [Google Scholar]
  20. Labro, M. T. ( 1998; ). Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 41, 37–46.[CrossRef]
    [Google Scholar]
  21. Matsuoka, M., Narita, M., Okazaki, N., Ohya, H., Yamazaki, T., Ouchi, K., Suzuki, I., Andoh, T., Kenri, T. & other authors ( 2004; ). Characterization and molecular analysis of macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained in Japan. Antimicrob Agents Chemother 48, 4624–4630.[CrossRef]
    [Google Scholar]
  22. Mizutani, H., Mizutani, H., Kitayama, T., Hayakawa, A., Nagayama, E., Kato, J., Nakamura, K., Tamura, E. & Izuchi, T. ( 1971; ). Delayed hypersensitivity in Mycoplasma pneumoniae infections. Lancet 1, 186–187.
    [Google Scholar]
  23. Nightingale, C. H. ( 1997; ). Pharmacokinetics and pharmacodynamics of newer macrolides. Pediatr Infect Dis J 16, 438–443.[CrossRef]
    [Google Scholar]
  24. Odenholt-Tornqvist, I., Löwdin, E. & Cars, O. ( 1995; ). Postantibiotic effects and postantibiotic sub-MIC effects of roxithromycin, clarithromycin, and azithromycin on respiratory tract pathogens. Antimicrob Agents Chemother 39, 221–226.[CrossRef]
    [Google Scholar]
  25. Okazaki, N., Narita, M., Yamada, S., Izumikawa, K., Umetsu, M., Kenri, T., Sasaki, Y., Arakawa, Y. & Sasaki, T. ( 2001; ). Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol Immunol 45, 617–620.[CrossRef]
    [Google Scholar]
  26. Prokesch, R. C. & Hand, W. L. ( 1982; ). Antibiotic entry into human polymorphonuclear leukocytes. Antimicrob Agents Chemother 21, 373–380.[CrossRef]
    [Google Scholar]
  27. Sekine, H., Tahuchi, H., Watanabe, H., Kawai, S., Fujioka, Y., Goto, H., Kobayashi, H. & Kamiya, S. ( 2009; ). Immunological analysis and pathological examination of gnotobiotic mice monoassociated with Mycoplasma pneumoniae. J Med Microbiol 58, 697–705.[CrossRef]
    [Google Scholar]
  28. Sohn, M. H., Lee, K. E., Choi, S. Y., Kwon, B. C., Chang, M. W. & Kim, K. E. ( 2005; ). Effect of Mycoplasma pneumoniae lysate on interleukin-8 gene expression in human respiratory epithelial cells. Chest 128, 322–326.
    [Google Scholar]
  29. Stutman, H. R. ( 1987; ). Stevens-Johnson syndrome and Mycoplasma pneumoniae: evidence for cutaneous infection. J Pediatr 111, 845–847.[CrossRef]
    [Google Scholar]
  30. Yamane, Y. & Kawai, C. ( 1978; ). A case of myocarditis caused by Mycoplasma pneumoniae. Jpn Circ J 42, 1279–1287.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.014191-0
Loading
/content/journal/jmm/10.1099/jmm.0.014191-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error