%0 Journal Article %A Oliveira, Naira Elane Moreira de %A Cavalcanti, Elisa D'Avila Costa %A Laport, Marinella Silva %A Bastos, Maria do Carmo de Freire %A Giambiagi-deMarval, Marcia %T Constitutive expression of the ileS-2 gene responsible for high-level mupirocin resistance in Staphylococcus aureus %D 2009 %J Journal of Medical Microbiology, %V 58 %N 12 %P 1582-1584 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.013912-0 %K IRS, isoleucyl-tRNA synthetase %K MRSA, meticillin-resistant Staphylococcus aureus %I Microbiology Society, %X Mupirocin is a topical antimicrobial agent that is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA). However, the prevalence of mupirocin resistance in S. aureus, particularly in MRSA, has increased. High-level mupirocin resistance, with MICs ≥512 μg ml−1, is mediated by the ileS-2 gene, which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the ileS-2 gene responsible for high-level mupirocin resistance, and we present some evidence that this gene is not upregulated but constitutively expressed in S. aureus. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.013912-0