1887

Abstract

Mupirocin is a topical antimicrobial agent that is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of meticillin-resistant (MRSA). However, the prevalence of mupirocin resistance in , particularly in MRSA, has increased. High-level mupirocin resistance, with MICs ≥512 μg ml, is mediated by the 2 gene, which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the gene responsible for high-level mupirocin resistance, and we present some evidence that this gene is not upregulated but constitutively expressed in .

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2009-12-01
2019-10-23
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