1887

Abstract

To analyse the characteristics of infections caused by subsp. , clinical isolates (=145) were collected at 11 medical institutions between September 2003 and October 2005. These isolates belonged to Lancefield group A (=5), group C (=18) or group G (=122). Among all isolates, 42 strains were isolated from sterile samples such as blood, synovial fluid and tissue specimens from patients who were mostly over 50 years with invasive infections, and included seven cases of streptococcal toxic shock syndrome and necrotizing fasciitis. In contrast, the remaining 103 were isolated mainly from patients of all age groups with non-invasive infections such as pharyngotonsillitis. These isolates were classified into 25 types based on genotyping. A significant difference in types was observed between isolates from invasive and non-invasive infections (<0.001): , and predominated among isolates from invasive infections. A phylogenetic tree of complete open reading frames of genes in this organism showed high homology with those of , but not with those of other streptococci. The presence of five different clones was estimated based on DNA profiles of isolates from invasive infections obtained by PFGE. Genes for resistance to macrolides [(A), three isolates; (B), five isolates; (A), seven isolates] and levofloxacin (mutations in and , four isolates) were identified in this organism. These results suggest the need for further nationwide surveillance of invasive infections caused by subsp. .

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2010-01-01
2019-10-19
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