RT Journal Article SR Electronic(1) A1 Naesens, Reinout A1 Ronsyn, Mark A1 Druwé, Patrick A1 Denis, Olivier A1 Ieven, Margareta A1 Jeurissen, AxelYR 2009 T1 Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus JF Journal of Medical Microbiology, VO 58 IS 9 SP 1247 OP 1251 DO https://doi.org/10.1099/jmm.0.011130-0 PB Microbiology Society, SN 1473-5644, AB We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.011130-0