%0 Journal Article %A Naesens, Reinout %A Ronsyn, Mark %A Druwé, Patrick %A Denis, Olivier %A Ieven, Margareta %A Jeurissen, Axel %T Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus %D 2009 %J Journal of Medical Microbiology, %V 58 %N 9 %P 1247-1251 %@ 1473-5644 %R https://doi.org/10.1099/jmm.0.011130-0 %K MRSA, meticillin-resistant Staphylococcus aureus %K CSF, cerebrospinal fluid %K CT, computed tomography %K CDC, Centers for Disease Control and Prevention %K PVL, Panton–Valentine leukocidin %K CNS, central nervous system %K CA, community-acquired %I Microbiology Society, %X We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.011130-0