@article{mbs:/content/journal/jmm/10.1099/jmm.0.011130-0, author = "Naesens, Reinout and Ronsyn, Mark and Druwé, Patrick and Denis, Olivier and Ieven, Margareta and Jeurissen, Axel", title = "Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus", journal= "Journal of Medical Microbiology", year = "2009", volume = "58", number = "9", pages = "1247-1251", doi = "https://doi.org/10.1099/jmm.0.011130-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.011130-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "MRSA, meticillin-resistant Staphylococcus aureus", keywords = "CSF, cerebrospinal fluid", keywords = "CT, computed tomography", keywords = "CDC, Centers for Disease Control and Prevention", keywords = "PVL, Panton–Valentine leukocidin", keywords = "CNS, central nervous system", keywords = "CA, community-acquired", abstract = "We report a case of community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) bacteraemia with cavernous sinus thrombosis, meningitis and brain abscess in a previously healthy American, who was employed in Belgium. We consecutively reviewed all published cases of CA-MRSA with central nervous system (CNS) involvement. A total of 12 similar cases were found, of which 11 were published in the last 4 years. Predominantly, young previously healthy subjects were affected (median age 28 years). The cases involved brain abscesses (5/12), disseminated disease (4/12), cavernous sinus thrombosis (2/12) and other (1/12). Infection origins were superficial skin infections (5/12), mostly of the face, sinusitis (1/12), otitis media (1/12), other or unknown (5/12). Although, in our review of the literature patients treated with linezolid had a better outcome compared to patients treated with vancomycin, the latter is still the mainstay of therapy for CNS infections associated with MRSA.", }